p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

Claudie Hooper, Eirini Meimaridou, Mahvash Tavassoli, Gerry Melino, Simon Lovestone, Richard Killick

Research output: Contribution to journalArticle

Abstract

p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalNeuroscience Letters
Volume418
Issue number1
DOIs
Publication statusPublished - May 11 2007

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Keywords

  • Alzheimer's disease
  • Microtubules
  • p53
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

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