p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Angela Santoro, Thalia Vlachou, Lucilla Luzi, Giorgio Melloni, Luca Mazzarella, Errico D'Elia, Xieraili Aobuli, Cristina Elisabetta Pasi, Linsey Reavie, Paola Bonetti, Simona Punzi, Lucia Casoli, Arianna Sabò, Maria Cristina Moroni, Gaetano Ivan Dellino, Bruno Amati, Francesco Nicassio, Luisa Lanfrancone, Pier Giuseppe Pelicci

Research output: Contribution to journalArticlepeer-review

Abstract

Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.

Original languageEnglish
Pages (from-to)624-638.e8
JournalCell Reports
Volume26
Issue number3
DOIs
Publication statusPublished - Jan 15 2019

Keywords

  • cancer maintenance
  • CSCs
  • mammary gland
  • Myc
  • p53
  • reprogramming
  • SC self-renewal

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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