p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Angela Santoro; Thalia Vlachou; Lucilla Luzi; Giorgio Melloni; Luca Mazzarella; Errico D'Elia; Xieraili Aobuli; Cristina Elisabetta Pasi; Linsey Reavie; Paola Bonetti; Simona Punzi; Lucia Casoli; Arianna Sabò; Maria Cristina Moroni; Gaetano Ivan Dellino; Bruno Amati; Francesco Nicassio; Luisa Lanfrancone; Pier Giuseppe Pelicci

doi:10.1016/j.celrep.2018.12.071

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Angela Santoro, Thalia Vlachou, Lucilla Luzi, Giorgio Melloni, Luca Mazzarella, Errico D'Elia, Xieraili Aobuli, Cristina Elisabetta Pasi, Linsey Reavie, Paola Bonetti, Simona Punzi, Lucia Casoli, Arianna Sabò, Maria Cristina Moroni, Gaetano Ivan Dellino, Bruno Amati, Francesco Nicassio, Luisa Lanfrancone, Pier Giuseppe Pelicci

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.

Original language	English
Pages (from-to)	624-638.e8
Journal	Cell Reports
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2018.12.071
Publication status	Published - Jan 15 2019

Keywords

cancer maintenance
CSCs
mammary gland
Myc
p53
reprogramming
SC self-renewal

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.celrep.2018.12.071

Cite this

Santoro, A., Vlachou, T., Luzi, L., Melloni, G., Mazzarella, L., D'Elia, E., Aobuli, X., Pasi, C. E., Reavie, L., Bonetti, P., Punzi, S., Casoli, L., Sabò, A., Moroni, M. C., Dellino, G. I., Amati, B., Nicassio, F., Lanfrancone, L., & Pelicci, P. G. (2019). p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Reports, 26(3), 624-638.e8. https://doi.org/10.1016/j.celrep.2018.12.071

Santoro, A, Vlachou, T, Luzi, L, Melloni, G, Mazzarella, L , D'Elia, E, Aobuli, X, Pasi, CE, Reavie, L, Bonetti, P, Punzi, S, Casoli, L, Sabò, A , Moroni, MC , Dellino, GI , Amati, B, Nicassio, F, Lanfrancone, L & Pelicci, PG 2019, 'p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value', Cell Reports, vol. 26, no. 3, pp. 624-638.e8. https://doi.org/10.1016/j.celrep.2018.12.071

@article{c89173ddb0fd4fb59a2c3391feda1bd6,

title = "p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value",

abstract = "Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.",

keywords = "cancer maintenance, CSCs, mammary gland, Myc, p53, reprogramming, SC self-renewal",

author = "Angela Santoro and Thalia Vlachou and Lucilla Luzi and Giorgio Melloni and Luca Mazzarella and Errico D'Elia and Xieraili Aobuli and Pasi, {Cristina Elisabetta} and Linsey Reavie and Paola Bonetti and Simona Punzi and Lucia Casoli and Arianna Sab{\`o} and Moroni, {Maria Cristina} and Dellino, {Gaetano Ivan} and Bruno Amati and Francesco Nicassio and Luisa Lanfrancone and Pelicci, {Pier Giuseppe}",

year = "2019",

month = jan,

day = "15",

doi = "10.1016/j.celrep.2018.12.071",

language = "English",

volume = "26",

pages = "624--638.e8",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

AU - Santoro, Angela

AU - Vlachou, Thalia

AU - Luzi, Lucilla

AU - Melloni, Giorgio

AU - Mazzarella, Luca

AU - D'Elia, Errico

AU - Aobuli, Xieraili

AU - Pasi, Cristina Elisabetta

AU - Reavie, Linsey

AU - Bonetti, Paola

AU - Punzi, Simona

AU - Casoli, Lucia

AU - Sabò, Arianna

AU - Moroni, Maria Cristina

AU - Dellino, Gaetano Ivan

AU - Amati, Bruno

AU - Nicassio, Francesco

AU - Lanfrancone, Luisa

AU - Pelicci, Pier Giuseppe

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.

AB - Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.

KW - cancer maintenance

KW - CSCs

KW - mammary gland

KW - Myc

KW - p53

KW - reprogramming

KW - SC self-renewal

UR - http://www.scopus.com/inward/record.url?scp=85059753189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059753189&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2018.12.071

DO - 10.1016/j.celrep.2018.12.071

M3 - Article

C2 - 30650356

AN - SCOPUS:85059753189

VL - 26

SP - 624-638.e8

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 3

ER -

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this