Santoro et al. demonstrate the existence of a regulatory axis instructed by the tumor-suppressor p53, executed by the Myc oncogene, and involving 189 p53:Myc targets. The authors show that activation of this axis maintains the expanding pool of cancer stem cells (SCs), thus promoting tumor growth, and predicts adverse prognosis.
- cancer maintenance
- mammary gland
- SC self-renewal
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)