p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

Consuelo Pitolli, Ying Wang, Eleonora Candi, Yufang Shi, Gerry Melino, Ivano Amelio

Research output: Contribution to journalReview article

Abstract

The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.

Original languageEnglish
JournalCancers
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 9 2019

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