p53 Over-expression and its correlation with PCNA index in nasal polyps

Anna Lavezzi; Mario Mantovani; Alessandra Cazzullo; Paola Turconi; Luigi Matturri

p53 Over-expression and its correlation with PCNA index in nasal polyps

Anna Lavezzi, Mario Mantovani, Alessandra Cazzullo, Paola Turconi, Luigi Matturri

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.

Original language	English
Pages (from-to)	160-163
Number of pages	4
Journal	Rhinology
Volume	37
Issue number	4
Publication status	Published - Dec 1999

Keywords

Epithelial cell proliferation
Immunohistochemistry nasal polyps p53 mutation
Proliferating cell nuclear antigen

ASJC Scopus subject areas

Otorhinolaryngology

Cite this

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title = "p53 Over-expression and its correlation with PCNA index in nasal polyps",

abstract = "Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.",

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AU - Lavezzi, Anna

AU - Mantovani, Mario

AU - Cazzullo, Alessandra

AU - Turconi, Paola

AU - Matturri, Luigi

PY - 1999/12

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N2 - Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.

AB - Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.

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p53 Over-expression and its correlation with PCNA index in nasal polyps

Abstract

Keywords

ASJC Scopus subject areas

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