p53 Over-expression and its correlation with PCNA index in nasal polyps

Anna Lavezzi, Mario Mantovani, Alessandra Cazzullo, Paola Turconi, Luigi Matturri

Research output: Contribution to journalArticle

Abstract

Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalRhinology
Volume37
Issue number4
Publication statusPublished - Dec 1999

Keywords

  • Epithelial cell proliferation
  • Immunohistochemistry nasal polyps p53 mutation
  • Proliferating cell nuclear antigen

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Lavezzi, A., Mantovani, M., Cazzullo, A., Turconi, P., & Matturri, L. (1999). p53 Over-expression and its correlation with PCNA index in nasal polyps. Rhinology, 37(4), 160-163.