Abstract
Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.
| Original language | English |
|---|---|
| Pages (from-to) | 160-163 |
| Number of pages | 4 |
| Journal | Rhinology |
| Volume | 37 |
| Issue number | 4 |
| Publication status | Published - Dec 1999 |
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Keywords
- Epithelial cell proliferation
- Immunohistochemistry nasal polyps p53 mutation
- Proliferating cell nuclear antigen
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
p53 Over-expression and its correlation with PCNA index in nasal polyps. / Lavezzi, Anna; Mantovani, Mario; Cazzullo, Alessandra; Turconi, Paola; Matturri, Luigi.
In: Rhinology, Vol. 37, No. 4, 12.1999, p. 160-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - p53 Over-expression and its correlation with PCNA index in nasal polyps
AU - Lavezzi, Anna
AU - Mantovani, Mario
AU - Cazzullo, Alessandra
AU - Turconi, Paola
AU - Matturri, Luigi
PY - 1999/12
Y1 - 1999/12
N2 - Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.
AB - Our knowledge about the etiopathogenesis of nasal polyps (Nps) is still limited. In this study, in order to define the biological features of these neoformations, we investigated with immunohistochemistry the p53 over- expression and the proliferating cell nuclear antigen (PCNA) in 32 cases of Nps and in normal mucosa of 11 control cases. The evaluation of PCNA showed a wide range of indices (0.5-18.2%) with a mean value (6.8%) significantly higher than in normal mucosa (2.9%). Over-expression of the p53 oncoprotein, observed in 50% of Nps, was statistically related to a high PCNA-index (>6.8%). Our results suggest that Nps can behave, in a high percentage of cases, like tumours.
KW - Epithelial cell proliferation
KW - Immunohistochemistry nasal polyps p53 mutation
KW - Proliferating cell nuclear antigen
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UR - http://www.scopus.com/inward/citedby.url?scp=0033385222&partnerID=8YFLogxK
M3 - Article
C2 - 10670029
AN - SCOPUS:0033385222
VL - 37
SP - 160
EP - 163
JO - Rhinology
JF - Rhinology
SN - 0300-0729
IS - 4
ER -