p53 Predictive Value for pT1-2 N0 Disease at Radical Cystectomy

Shahrokh F. Shariat, Yair Lotan, Pierre I. Karakiewicz, Raheela Ashfaq, Hendrik Isbarn, Yves Fradet, Patrick J. Bastian, Matthew E. Nielsen, Umberto Capitanio, Claudio Jeldres, Francesco Montorsi, Stefan C. Müller, Jose A. Karam, Lukas C. Heukamp, George Netto, Seth P. Lerner, Arthur I. Sagalowsky, Richard J. Cote

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Approximately 15% to 30% of patients with pT1-2N0M0 urothelial carcinoma of the bladder experience disease progression despite radical cystectomy with curative intent. We determined whether p53 expression would improve the prediction of disease progression after radical cystectomy for pT1-2N0M0 UCB. Materials and Methods: In a multi-institutional retrospective cohort we identified 324 patients with pT1-2N0M0 urothelial carcinoma of the bladder who underwent radical cystectomy. Analysis focused on a testing cohort of 272 patients and an external validation of 52. Competing risks regression models were used to test the association of variables with cancer specific mortality after accounting for nonbladder cancer caused mortality. Results: In the testing cohort 91 patients (33.5%) had altered p53 expression (p53alt). On multivariate competing risks regression analysis altered p53 achieved independent status for predicting disease recurrence and cancer specific mortality (each p

Original languageEnglish
Pages (from-to)907-913
Number of pages7
JournalJournal of Urology
Volume182
Issue number3
DOIs
Publication statusPublished - Sep 2009

Keywords

  • carcinoma
  • genes
  • mortality
  • p53
  • urinary bladder
  • urothelium

ASJC Scopus subject areas

  • Urology

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