p53 protein expression in laryngeal squamous cell carcinomas bearing wild-type and mutated p53 gene

G. Pruneri, L. Pignataro, N. S. Fracchiolla, S. Ferrero, P. Capaccio, N. Carboni, A. Ottaviani, A. T. Maiolo, A. Neri, R. Buffa

Research output: Contribution to journalArticle

Abstract

We performed an immunohistochemical analysis to investigate the expression of p53 protein in a panel of 18 laryngeal squamous cell carcinomas, 15 primary tumours and three in relapse, previously analysed by us for the presence of p53 gene mutations. Dysplastic and/or normal surrounding mucosa was evaluated in 15 different tumours. The results of our study are the following: (1) expression of p53 protein was observed in one out of five tumours positive for p53 gene mutations (20%) and in 10 out of 13 (80%) negative cases; (2), p53 protein overexpression was frequently observed in normal and/or dysplastic mucosa surrounding either wild-type (7/11) or mutated p53 tumours (2/4); (3), p53 immunoreactive cells showed a pattern of distribution in normal and mildly/moderately dysplastic mucosa (basal layers), different from that in severely dysplastic mucosa (whole thickness). These data further support the hypothesis that p53 protein over-expression may be a marker of the earliest phases of multistep tumorigenesis in laryngeal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)513-519
Number of pages7
JournalHistopathology
Volume28
Issue number6
Publication statusPublished - 1996

Keywords

  • Laryngeal squamous cell carcinoma
  • p53 gene mutation
  • p53 protein expression

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'p53 protein expression in laryngeal squamous cell carcinomas bearing wild-type and mutated p53 gene'. Together they form a unique fingerprint.

  • Cite this