p53 protein over-expression and p53 gene abnormalities in HIV-1-related non-Hodgkin's lymphomas

V. De Re, A. Carbone, S. De Vita, A. Gloghini, R. Maestro, D. Gasparotto, T. Vukosavljevic, M. Boioccho

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Abstract

Alteration of the p53 tumor-suppressor gene was studied in non-Hodgkin's lymphomas (NHLs) from HIV-1-infected patients. p53 protein was over-expressed in 10 out of the 45 (22%) cases analyzed, mainly clustering in the small-non-cleaved-cell (SNC) (5/19) and Ki-1+ anaplastic large-cell (ALC) (3/8) subtypes, according to previous findings on HIV-1-unrelated NHLs. p53-positive small-non-cleaved-cell lymphomas presented a diffuse or clustered pattern of p53-positive neoplastic cells consequent upon p53-gene mutations. In contrast, in Ki-1+ ALC lymphomas p53 immunohistochemical reactivity was limited to scattered tumor cells, and no p53-gene alterations could be detected. These results suggest that p53-gene alterations play a role in the lymphomagnetic process of a fraction of HIV-1-related SNC NHLs, however with a frequency no different from that observed in HIV-1-unrelated NHLs of the same sub-type. In HIV-1-related Ki-1+ ALC lymphomas, mechanisms different from gene alterations might be implicated in over-expression of p53 protein.

Original languageEnglish
Pages (from-to)662-667
Number of pages6
JournalInternational Journal of Cancer
Volume56
Issue number5
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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