P53 role in DNA repair and tumorigenesis

S. Soddu, A. Sacchi

Research output: Contribution to journalArticlepeer-review


The p53 oncosuppressor is the gene which has been found to be most frequently altered in human cancers. How the p53 gene contributes to tumor induction and progression is presently being investigated by numerous researchers whose specialties range from basic science to clinics. This is a brief overview of the hypotheses on p53 role in tumorigenesis and the possible use of p53 analyses in tumor prognosis and therapy.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Issue number3
Publication statusPublished - Sep 1997


  • Apoptosis
  • Genome stability
  • Oncosuppressor
  • P53
  • Tumor progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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