P53 tumour suppressor gene and RAS oncogenes: Molecular analysis in the chronic and leukaemic phases of essential thrombocythaemia

Antonino Neri, Nicola Stefano Fracchiolla, Franca Radaelli, Alketa Boletini, Sonia Ribera, Chiara Migliorini, Dino Trecca, Anna Teresa Maiolo

Research output: Contribution to journalArticle

Abstract

A panel of 51 cases of essential thrombocythaemia (ET), in chronic or leukaemic phase, was investigated for p53 gene and RAS oncogenes mutations by PCR-SSCP-direct sequencing. No RAS oncogenes mutations were detected, but p53 mutations were identified in three cases: 1/27 cases (~4%) in chronic phase not undergoing chemotherapy, 1/19 cases (~5%) in chronic phase undergoing chemotherapy, and 1/5 cases (20%) which had progressed to leukaemia. Our results suggest that: (1) p53 gene mutations occur sporadically in the chronic phase of ET, independent of chemotherapy, and may contribute to the progression to the leukaemic phase in a limited number of ET patients; (2) the RAS genes family does not seem to be involved in the pathogenesis of ET, unlike other bcr/abl negative chronic myeloproliferative diseases (CMPDs).

Original languageEnglish
Pages (from-to)670-673
Number of pages4
JournalBritish Journal of Haematology
Volume93
Issue number3
Publication statusPublished - 1996

Keywords

  • Essential thrombocythaemia
  • Leukaemic phase
  • p53
  • RAS

ASJC Scopus subject areas

  • Hematology

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