P63, a story of mice and men

Hans Vanbokhoven, Gerry Melino, Eleonora Candi, Wim Declercq

Research output: Contribution to journalArticlepeer-review

Abstract

The transcription factor p63 is essential for the formation of the epidermis and other stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient mice and by the development of certain types of ectodermal dysplasias in humans as a result of p63 mutations. Investigation of the in vivo functions of p63 is complicated by the occurrence of 10 different splicing isoforms and by its interaction with the other family members, p53 and p73. In vitro and in vivo models have been used to unravel the functions of p63 and its different isoforms, but the results or their interpretation are often contradictory. This review focuses on what mammalian in vivo models and patient studies have taught us in the last 10 years.

Original languageEnglish
Pages (from-to)1196-1207
Number of pages12
JournalJournal of Investigative Dermatology
Volume131
Issue number6
DOIs
Publication statusPublished - Jun 2011

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

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