Abstract
p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.
Original language | English |
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Pages (from-to) | 1204-1206 |
Number of pages | 3 |
Journal | Journal of Investigative Dermatology |
Volume | 137 |
Issue number | 6 |
DOIs |
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Publication status | Published - Jun 1 2017 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology