p63 Adjusts Sugar Taste of Epidermal Layers

Ivano Amelio; Gerry Melino; Eleonora Candi

doi:10.1016/j.jid.2017.02.967

p63 Adjusts Sugar Taste of Epidermal Layers

Ivano Amelio, Gerry Melino, Eleonora Candi

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.

Original language	English
Pages (from-to)	1204-1206
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	137
Issue number	6
DOIs	https://doi.org/10.1016/j.jid.2017.02.967
Publication status	Published - Jun 1 2017

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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title = "p63 Adjusts Sugar Taste of Epidermal Layers",

abstract = "p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.",

author = "Ivano Amelio and Gerry Melino and Eleonora Candi",

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AU - Amelio, Ivano

AU - Melino, Gerry

AU - Candi, Eleonora

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N2 - p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.

AB - p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.

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p63 Adjusts Sugar Taste of Epidermal Layers

Abstract

ASJC Scopus subject areas

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