p63 Adjusts Sugar Taste of Epidermal Layers

Ivano Amelio, Gerry Melino, Eleonora Candi

Research output: Contribution to journalComment/debatepeer-review

Abstract

p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.

Original languageEnglish
Pages (from-to)1204-1206
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint Dive into the research topics of 'p63 Adjusts Sugar Taste of Epidermal Layers'. Together they form a unique fingerprint.

Cite this