p63 controls cell migration and invasion by transcriptional regulation of MTSS1

A. Giacobbe, M. Compagnone, L. Bongiorno-Borbone, A. Antonov, E. K. Markert, J. H. Zhou, M. Annicchiarico-Petruzzelli, G. Melino, A. Peschiaroli

Research output: Contribution to journalArticle

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Abstract

Metastasis is a multistep cell-biological process, which is orchestrated by many factors, including metastasis activators and suppressors. Metastasis Suppressor 1 (MTSS1) was originally identified as a metastasis suppressor protein whose expression is lost in metastatic bladder and prostate carcinomas. However, recent findings indicate that MTSS1 acts as oncogene and pro-migratory factor in melanoma tumors. Here, we identify and characterized a molecular mechanism controlling MTSS1 expression, which impinges on a pro-tumorigenic role of MTSS1 in breast tumors. We found that in normal and in cancer cell lines ΔNp63 is able to drive the expression of MTSS1 by binding to a p63-binding responsive element localized in the MTSS1 locus. We reported that ΔNp63 is able to drive the migration of breast tumor cells by inducing the expression of MTSS1. Notably, in three human breast tumors data sets the MTSS1/p63 co-expression is a negative prognostic factor on patient survival, suggesting that the MTSS1/p63 axis might be functionally important to regulate breast tumor progression.Oncogene advance online publication, 29 June 2015; doi:10.1038/onc.2015.230.

Original languageEnglish
JournalOncogene
DOIs
Publication statusAccepted/In press - Jun 29 2015

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Cell Movement
Neoplasm Metastasis
Breast Neoplasms
Oncogenes
Tumor Suppressor Proteins
Biological Phenomena
Publications
Prostate
Melanoma
Neoplasms
Urinary Bladder
Carcinoma
Cell Line
Survival

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Giacobbe, A., Compagnone, M., Bongiorno-Borbone, L., Antonov, A., Markert, E. K., Zhou, J. H., ... Peschiaroli, A. (Accepted/In press). p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene. https://doi.org/10.1038/onc.2015.230

p63 controls cell migration and invasion by transcriptional regulation of MTSS1. / Giacobbe, A.; Compagnone, M.; Bongiorno-Borbone, L.; Antonov, A.; Markert, E. K.; Zhou, J. H.; Annicchiarico-Petruzzelli, M.; Melino, G.; Peschiaroli, A.

In: Oncogene, 29.06.2015.

Research output: Contribution to journalArticle

Giacobbe, A, Compagnone, M, Bongiorno-Borbone, L, Antonov, A, Markert, EK, Zhou, JH, Annicchiarico-Petruzzelli, M, Melino, G & Peschiaroli, A 2015, 'p63 controls cell migration and invasion by transcriptional regulation of MTSS1', Oncogene. https://doi.org/10.1038/onc.2015.230
Giacobbe A, Compagnone M, Bongiorno-Borbone L, Antonov A, Markert EK, Zhou JH et al. p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene. 2015 Jun 29. https://doi.org/10.1038/onc.2015.230
Giacobbe, A. ; Compagnone, M. ; Bongiorno-Borbone, L. ; Antonov, A. ; Markert, E. K. ; Zhou, J. H. ; Annicchiarico-Petruzzelli, M. ; Melino, G. ; Peschiaroli, A. / p63 controls cell migration and invasion by transcriptional regulation of MTSS1. In: Oncogene. 2015.
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