Abstract
To analyse the relationship of the immunohistochemical p63 expression with tumoral extent, histologic grade, lymph node involvement and clinical stage in laryngeal squamous cell carcinoma (LSCC), a series of 81 patients with primary LSCC treated by primary surgery was retrospectively evaluated. Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissue blocks from surgical samples. Clinicopathologic data were correlated with the p63 staining results. Differences in p63 immunoreactivity between the different groups were compared using both parametric analysis of variance (ANOVA) and non-parametric Kruskal-Wallis test. Statistical signiflcance was set at p
Original language | English |
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Pages (from-to) | 121-129 |
Number of pages | 9 |
Journal | Journal of Biological Regulators and Homeostatic Agents |
Volume | 27 |
Issue number | 1 |
Publication status | Published - 2013 |
Keywords
- Biomarker
- Laryngeal squamous cell carcinoma
- p63 immunostaining
- Prognosis
ASJC Scopus subject areas
- Oncology
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
- Immunology and Allergy
- Immunology
- Endocrinology
- Physiology
- Cancer Research