p63 expression in laryngeal squamous cell carcinoma is related to tumor extension, histologic grade, lymph node involvement and clinical stage

Massimo Re, G. Magliulo, L. Ferrante, A. Zizzi, A. Santarelli, D. Stramazzotti, L. Lo Muzio, G. Goteri, C. Rubini

Research output: Contribution to journalArticlepeer-review

Abstract

To analyse the relationship of the immunohistochemical p63 expression with tumoral extent, histologic grade, lymph node involvement and clinical stage in laryngeal squamous cell carcinoma (LSCC), a series of 81 patients with primary LSCC treated by primary surgery was retrospectively evaluated. Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissue blocks from surgical samples. Clinicopathologic data were correlated with the p63 staining results. Differences in p63 immunoreactivity between the different groups were compared using both parametric analysis of variance (ANOVA) and non-parametric Kruskal-Wallis test. Statistical signiflcance was set at p

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalJournal of Biological Regulators and Homeostatic Agents
Volume27
Issue number1
Publication statusPublished - 2013

Keywords

  • Biomarker
  • Laryngeal squamous cell carcinoma
  • p63 immunostaining
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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