p63 expression in salivary gland tumors: Role of ΔNp73L in neoplastic transformation

Maria P. Foschini, Alessia Gaiba, Roberto Cocchi, Maria G. Pennesi, Annalisa Pession

Research output: Contribution to journalArticlepeer-review

Abstract

To illustrate the role of p63 and its truncated variants in salivary gland tumors, 23 consecutive tumors and 6 normal salivary glands were studied immunohistochemically with anti-p63 antibody and by reverse transcriptase (RT) and nested polymerase chain reaction (PCR) to detect p63 isoform expression. Normal salivary glands: p63 antibody-stained basal and myoepithelial cells; by RT and nested PCR, the 2 main isoforms were present, whereas ANp73L was absent. Tumors: p63 antibody was positive in the following: Warthin tumor (WT) (3/3), oncocytoma (OC) (1/1), pleomorphic adenoma (PA) (7/7), polymorphous-low-grade adenocarcinoma (PLGA) (3/3), adenoid-cystic carcinoma (ADCC)(3/4), epithelial-myoepithelial-cell carcinoma (EMC) (1/1), and myoepithelial-cell carcinoma (MCC) (1/1). By RT and nested PCR all tumors expressed p63 irrespective of their morphologic differentiation. The ANp73L isoform was present in tumoral tissue but absent in normal salivary gland. These data suggest that p63, particularly its splice variant ANp73L, is involved in the neoplastic transformation of salivary glands.

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalInternational Journal of Surgical Pathology
Volume13
Issue number4
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Δnp73l
  • Basal cell
  • Myoepithelium
  • p63
  • Salivary gland tumor
  • Splice variant

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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