p63 immunoreactivity in lung cancer: Yet another player in the development of squamous cell carcinomas?

Giuseppe Pelosi, Felice Pasini, Catharina Olsen Stenholm, Ugo Pastorino, Patrick Maisonneuve, Angelica Sonzogni, Fausto Maffini, Giancarlo Pruneri, Filippo Fraggetta, Alessandra Cavallon, Elena Roz, Antonio Iannucci, Enrica Bresaola, Giuseppe Viale

Research output: Contribution to journalArticle

Abstract

The p63 protein, a member of the p53 family of nuclear transcription factors, is characterized by different capabilities of transactivating reporter genes, inducing apoptosis, and functioning as dominant-negative agent. This study evaluated the prevalence and prognostic implications of p63 immunoreactivity in 221 patients with stage I non-small cell lung carcinoma (NSCLC) and in 57 patients with stage I-IV neuroendocrine tumours (NET). The results were correlated with the tumour proliferative fraction, the accumulation of p53 protein, and with patient survival. p63 immunoreactivity was seen in 109/118 squamous cell carcinomas, 15/95 adenocarcinomas, 2/2 adenosquamous carcinomas, 4/6 large cell carcinomas, 9/20 poorly differentiated NET, and 1/37 typical and atypical carcinoids (P <0.001). Furthermore, the prevalence of p63-immunoreactive cells increased progressively from pre-neoplastic and pre-invasive lesions to invasive squamous cell carcinomas. In these latter tumours, but not in adenocarcinomas, p63 immunoreactivity correlated directly with the tumour proliferative fraction (p = 0.028), and inversely with the tumour grade (p = 0.004). No relationship was found with p53 protein immunoreactivity or the other clinico-pathological variables examined. Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalJournal of Pathology
Volume198
Issue number1
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Adenocarcinoma
  • Immunohistochemistry
  • Neuroendocrine tumours
  • Non-small cell lung cancer
  • p63 protein
  • Prognosis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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