P63 in tooth development

Alessandro Rufini, Alberto Barlattani, Raffaella Docimo, Tania Velletri, Maria Victoria Niklison-Chirou, Massimiliano Agostini, Gerry Melino

Research output: Contribution to journalArticlepeer-review

Abstract

Recent findings have shown that the development of teeth involves a complex sequence of molecular events in which the p53 family member p63 is involved. Indeed, mice lacking p63 do not have teeth and humans bearing mutations in p63 suffer developmental syndromes that affect tooth morphology and number. Several isoforms of p63 have been described: the use of two different promoters produces longer TAp63 isoforms, or shorter, 5′ truncated isoforms known as ΔNp63. The 3′ end of primary transcripts is then subject to alternative splicing resulting in three additional isoforms: alpha (α), beta (β) and gamma (γ). Tooth development relies mainly on the activity of the N-terminally truncated ΔNp63 isoforms. Here we review the experimental evidence for the involvement of ΔNp63 in tooth development through its ability to sustain the molecular signalling that orchestrates epithelial-mesenchymal interaction.

Original languageEnglish
Pages (from-to)1256-1261
Number of pages6
JournalBiochemical Pharmacology
Volume82
Issue number10
DOIs
Publication statusPublished - Nov 15 2011

Keywords

  • Epidermis
  • FGF
  • Notch
  • p63
  • Tooth development

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

Fingerprint Dive into the research topics of 'P63 in tooth development'. Together they form a unique fingerprint.

Cite this