P63 is a promising marker in the diagnosis of unusual skin cancer

Artem Smirnov, Lucia Anemona, Flavia Novelli, Cristina M. Piro, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Eleonora Candi

Research output: Contribution to journalReview articlepeer-review

Abstract

Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case of melanoma. Therefore, good diagnostic and prognostic markers are needed to ensure correct detection and treatment. Transcription factor p63, a member of the p53 family of proteins, plays an essential role in the development of stratified epithelia such as skin. In this paper, we conduct a comprehensive review of p63 expression in different types of skin cancer and discuss its possible use in the diagnosis and prognosis of cutaneous tumours.

Original languageEnglish
Article number5781
JournalInternational Journal of Molecular Sciences
Volume20
Issue number22
DOIs
Publication statusPublished - Nov 2 2019

Keywords

  • Basal cell carcinoma
  • Merkel cell carcinoma
  • P40
  • P63
  • Skin cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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