p63 overexpression associates with poor prognosis in head and neck squamous cell carcinoma

Lorenzo Lo Muzio, Andrea Santarelli, Rosario Caltabiano, Corrado Rubini, Tiziana Pieramici, Lorenzo Trevisiol, Francesco Carinci, Rosalia Leonardi, Alfredo De Lillo, Salvatore Lanzafame, Pantaleo Bufo, Adriano Piattelli

Research output: Contribution to journalArticlepeer-review

Abstract

p63 belongs to a protein family that includes 2 structurally related proteins, p53 and p73. The aim of this study was to investigate the biologic role of p63 in oral tumorigenesis and its possible role as prognostic marker in oral cancer. Ninety-four cases of oral squamous cell carcinoma and 10 cases of normal mucosa were analyzed for p63 expression by immunohistochemistry. Normal oral mucosa showed a basal and parabasal expression of p63. Five (5.3%) cases of oral cancer showed less than 10% of positive tumor cells; in 33 (35.1%) cases the positive tumor cells comprised between 10% and less than 30%, in 36 (38.3%) cases the positive tumor cells comprised between 30% and less than 50%, and in 20 (21.3%) cases the positive tumor cells were more than 50%. There was also a statistically significant correlation between p63 expression and tumor differentiation: p63 expression was amplified in poorly differentiated tumors (P

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalHuman Pathology
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Apoptosis
  • HNSCC
  • Oral cancer
  • p63
  • Prognosis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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