TY - JOUR
T1 - p66Shc protein, oxidative stress, and cardiovascular complications of diabetes
T2 - The missing link
AU - Francia, Pietro
AU - Cosentino, Francesco
AU - Schiavoni, Marzia
AU - Huang, Yale
AU - Perna, Enrico
AU - Camici, Giovani G.
AU - Lüscher, Thomas F.
AU - Volpe, Massimo
PY - 2009/9
Y1 - 2009/9
N2 - Diabetes affects more than 150 million people worldwide, and it is estimated that this would increase to 299 million by the year 2025. The incidence of and mortality from cardiovascular disease are two- to eightfold higher in subjects with diabetes than in those without, coronary artery disease accounting for the large majority of deaths. Among the full spectrum of biochemical effects of high glucose, generation of oxygen-derived free radicals is one of the main pathophysiological mechanisms linking hyperglycemia to atherosclerosis, nephropathy, and cardiomyopathy. The adaptor protein p66 Shc is implicated in mitochondrial reactive oxygen species (ROS) generation and translation of oxidative signals into apoptosis. Indeed, p66 Shc-/- mice display prolonged lifespan, reduced production of intracellular oxidants, and increased resistance to oxidative stress-induced apoptosis. Accordingly, a series of studies defined the pathophysiological role of p66Shc in cardiovascular disease where ROS represent a substantial triggering component. As p66Shc modulates the production of cellular ROS, it represents a proximal node through which high glucose exerts its deleterious effects on different cell types; indeed, several studies tested the hypothesis that deletion of the p66Shc gene may confer protection against diabetes-related cardiovascular complications. The present review focuses on the reported evidence linking p66Shc signaling pathway to high glucose-associated endothelial dysfunction, atherogenesis, nephropathy, and cardiomyopathy.
AB - Diabetes affects more than 150 million people worldwide, and it is estimated that this would increase to 299 million by the year 2025. The incidence of and mortality from cardiovascular disease are two- to eightfold higher in subjects with diabetes than in those without, coronary artery disease accounting for the large majority of deaths. Among the full spectrum of biochemical effects of high glucose, generation of oxygen-derived free radicals is one of the main pathophysiological mechanisms linking hyperglycemia to atherosclerosis, nephropathy, and cardiomyopathy. The adaptor protein p66 Shc is implicated in mitochondrial reactive oxygen species (ROS) generation and translation of oxidative signals into apoptosis. Indeed, p66 Shc-/- mice display prolonged lifespan, reduced production of intracellular oxidants, and increased resistance to oxidative stress-induced apoptosis. Accordingly, a series of studies defined the pathophysiological role of p66Shc in cardiovascular disease where ROS represent a substantial triggering component. As p66Shc modulates the production of cellular ROS, it represents a proximal node through which high glucose exerts its deleterious effects on different cell types; indeed, several studies tested the hypothesis that deletion of the p66Shc gene may confer protection against diabetes-related cardiovascular complications. The present review focuses on the reported evidence linking p66Shc signaling pathway to high glucose-associated endothelial dysfunction, atherogenesis, nephropathy, and cardiomyopathy.
KW - Cardiovascular disease
KW - Diabetes
KW - Oxidative stress
KW - p66
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U2 - 10.1007/s00109-009-0499-3
DO - 10.1007/s00109-009-0499-3
M3 - Article
C2 - 19590843
AN - SCOPUS:68949209647
VL - 87
SP - 885
EP - 891
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
SN - 0946-2716
IS - 9
ER -