P66Shc signals to age.

Mirella Trinei; Ina Berniakovich; Elena Beltrami; Enrica Migliaccio; Ambrogio Fassina; PierGiuseppe Pelicci; Marco Giorgio

P66Shc signals to age.

Mirella Trinei, Ina Berniakovich, Elena Beltrami, Enrica Migliaccio, Ambrogio Fassina, PierGiuseppe Pelicci, Marco Giorgio

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.

Original language	English
Pages (from-to)	503-510
Number of pages	8
Journal	Aging
Volume	1
Issue number	6
Publication status	Published - Jun 2009

ASJC Scopus subject areas

Geriatrics and Gerontology

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title = "P66Shc signals to age.",

abstract = "Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.",

author = "Mirella Trinei and Ina Berniakovich and Elena Beltrami and Enrica Migliaccio and Ambrogio Fassina and PierGiuseppe Pelicci and Marco Giorgio",

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AU - Trinei, Mirella

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AU - Beltrami, Elena

AU - Migliaccio, Enrica

AU - Fassina, Ambrogio

AU - Pelicci, PierGiuseppe

AU - Giorgio, Marco

PY - 2009/6

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AB - Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.

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