P66Shc signals to age.

Mirella Trinei, Ina Berniakovich, Elena Beltrami, Enrica Migliaccio, Ambrogio Fassina, PierGiuseppe Pelicci, Marco Giorgio

Research output: Contribution to journalArticlepeer-review


Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
Issue number6
Publication statusPublished - Jun 2009

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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