P66ShcA: Linking Mammalian Longevity with Obesity-Induced Insulin Resistance

Sofia Chiatamone Ranieri, Salvatore Fusco, Giovambattista Pani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Traditionally linked to an accumulation of cell and tissue oxidative damage, the aging process is currently viewed as the result of a chronic metabolic imbalance and deranged body response to nutrients. This is in keeping with the pivotal role of the insulin/IGF pathway in longevity determination from model organisms to primates, with the association between obesity and age-related disorders, and with the dramatic acceleration of senescence by diabetes. Importantly, metabolic and oxidative damages concomitantly occur in aging as consequences of tissue hyperstimulation by insulin.With its double identity of generator of mitochondrial oxidant species and of signaling adaptor in the insulin receptor cascade, the 66Kd Shc protein (p66Shc) has drawn major attention as a negative determinant of life span and healthy longevity in mammals. We have demonstrated that these effects are related, at least in part, to p66Shc effect on the mTOR/S6K cascade that promotes obesity and insulin resistance and shortens life span.

Original languageEnglish
Pages (from-to)219-241
Number of pages23
JournalVitamins and Hormones
Volume91
DOIs
Publication statusPublished - 2013

Fingerprint

Insulin Resistance
Obesity
Insulin
Insulin Receptor
Oxidants
Primates
Mammals
Food
Proteins

Keywords

  • Adipose tissue
  • Aging
  • Calorie restriction
  • Diabetes
  • IGF-1/insulin signaling
  • MTOR/S6K
  • P66Shc

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

P66ShcA : Linking Mammalian Longevity with Obesity-Induced Insulin Resistance. / Ranieri, Sofia Chiatamone; Fusco, Salvatore; Pani, Giovambattista.

In: Vitamins and Hormones, Vol. 91, 2013, p. 219-241.

Research output: Contribution to journalArticle

Ranieri, Sofia Chiatamone ; Fusco, Salvatore ; Pani, Giovambattista. / P66ShcA : Linking Mammalian Longevity with Obesity-Induced Insulin Resistance. In: Vitamins and Hormones. 2013 ; Vol. 91. pp. 219-241.
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