p73: A multifunctional protein in neurobiology

Richard Killick, Maria Niklison-Chirou, Richard Tomasini, Daniele Bano, Alessandro Rufini, Francesca Grespi, Tania Velletri, Paola Tucci, Berna S. Sayan, Franco Conforti, Ewen Gallagher, Pierluigi Nicotera, Tak W. Mak, Gerry Melino, Richard A. Knight, Massimiliano Agostini

Research output: Contribution to journalArticle

Abstract

P73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and ΔNp73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, ΔNp73 shows a survival function in mature cortical neurons as selective ΔNp73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer's disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalMolecular Neurobiology
Volume43
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Alzheimer's disease
  • Neural stem cells (NSC)
  • Neurodegeneration
  • Neuronal differentiation
  • P73

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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  • Cite this

    Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., Velletri, T., Tucci, P., Sayan, B. S., Conforti, F., Gallagher, E., Nicotera, P., Mak, T. W., Melino, G., Knight, R. A., & Agostini, M. (2011). p73: A multifunctional protein in neurobiology. Molecular Neurobiology, 43(2), 139-146. https://doi.org/10.1007/s12035-011-8172-6