P73 and age-related diseases: Is there any link with parkinson disease?

Francesca Grespi, Gerry Melino

Research output: Contribution to journalArticle

Abstract

P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many agerelated neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson disease being the enzyme necessary for dopamine synthesis. In this work we show that levels of tyrosine hydroxylase can be influenced by p73. We also demonstrate that p73 can protect against tyrosine hydroxylase depletion in an in vitro model of Parkinson disease.

Original languageEnglish
Pages (from-to)923-931
Number of pages9
JournalAging
Volume4
Issue number12
Publication statusPublished - Dec 2012

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Keywords

  • Cell death
  • Neurodegeneration
  • P73
  • Parkinson disease
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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