p73: Friend or foe in tumorigenesis

Gerry Melino, Vincenzo De Laurenzi, Karen H. Vousden

Research output: Contribution to journalArticle

Abstract

As p53 and its homologue p73 have significant sequence and functional similarities, p73 might also be expected to act as a tumour suppressor. However, p73 is activated after DNA damage in a way that is distinct from that of p53. The existence of ΔNp73 - an isoform of p73 that is encoded by a distinct promoter and that lacks the transactivation domain - further complicates matters. It seems to function as an oncogene by inhibiting both p73- and p53-induced apoptosis. So how can these opposing functions be reconciled in human tumours?

Original languageEnglish
Pages (from-to)605-615
Number of pages11
JournalNature Reviews Cancer
Volume2
Issue number8
DOIs
Publication statusPublished - Aug 2002

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Carcinogenesis
Oncogenes
Transcriptional Activation
DNA Damage
Neoplasms
Protein Isoforms
Apoptosis

ASJC Scopus subject areas

  • Cancer Research

Cite this

p73 : Friend or foe in tumorigenesis. / Melino, Gerry; De Laurenzi, Vincenzo; Vousden, Karen H.

In: Nature Reviews Cancer, Vol. 2, No. 8, 08.2002, p. 605-615.

Research output: Contribution to journalArticle

Melino, G, De Laurenzi, V & Vousden, KH 2002, 'p73: Friend or foe in tumorigenesis', Nature Reviews Cancer, vol. 2, no. 8, pp. 605-615. https://doi.org/10.1038/nrc861
Melino, Gerry ; De Laurenzi, Vincenzo ; Vousden, Karen H. / p73 : Friend or foe in tumorigenesis. In: Nature Reviews Cancer. 2002 ; Vol. 2, No. 8. pp. 605-615.
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