p73: Friend or foe in tumorigenesis

Gerry Melino, Vincenzo De Laurenzi, Karen H. Vousden

Research output: Contribution to journalArticlepeer-review

Abstract

As p53 and its homologue p73 have significant sequence and functional similarities, p73 might also be expected to act as a tumour suppressor. However, p73 is activated after DNA damage in a way that is distinct from that of p53. The existence of ΔNp73 - an isoform of p73 that is encoded by a distinct promoter and that lacks the transactivation domain - further complicates matters. It seems to function as an oncogene by inhibiting both p73- and p53-induced apoptosis. So how can these opposing functions be reconciled in human tumours?

Original languageEnglish
Pages (from-to)605-615
Number of pages11
JournalNature Reviews Cancer
Volume2
Issue number8
DOIs
Publication statusPublished - Aug 2002

ASJC Scopus subject areas

  • Cancer Research

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