Pachydermoperiostosis. Ultrastructural and vascular observations

G. Nini, S. Calvieri, S. Gatti, S. Lupini, L. Bianchi, A. Di Carlo, A. M. Carrozzo, S. Iraci, C. Marinaro

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Abstract

A case of Pachydermoperiostois is described. The clinical course and the absence of primary, causative lesions indicate the primary idiopathic form of this case. Histological, ultrastructural, biochemical and vascular (thermography-reography) investigations were applied. The following findings are the most important remarks: a) Fibroblasts highly active and alterations of the basal membrane of the dermal vessels. b) Increased value of seric osteocalcin, a marker of new bone formation. c) Basal hypothermia at the thermography suggesting a reduced blood flow through the clubbed digits and an increased wave at the reography. The authors underline the increased activity of both fibroblasts and osteoblasts as pathogenetic clue of the hypertrophic dermo-osteopathy.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalGiornale Italiano di Dermatologia e Venereologia
Volume123
Issue number10
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Dermatology

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    Nini, G., Calvieri, S., Gatti, S., Lupini, S., Bianchi, L., Di Carlo, A., Carrozzo, A. M., Iraci, S., & Marinaro, C. (1988). Pachydermoperiostosis. Ultrastructural and vascular observations. Giornale Italiano di Dermatologia e Venereologia, 123(10), 481-487.