Pachydermoperiostosis. Ultrastructural and vascular observations

G. Nini, S. Calvieri, S. Gatti, S. Lupini, L. Bianchi, A. Di Carlo, A. M. Carrozzo, S. Iraci, C. Marinaro

Research output: Contribution to journalArticle


A case of Pachydermoperiostois is described. The clinical course and the absence of primary, causative lesions indicate the primary idiopathic form of this case. Histological, ultrastructural, biochemical and vascular (thermography-reography) investigations were applied. The following findings are the most important remarks: a) Fibroblasts highly active and alterations of the basal membrane of the dermal vessels. b) Increased value of seric osteocalcin, a marker of new bone formation. c) Basal hypothermia at the thermography suggesting a reduced blood flow through the clubbed digits and an increased wave at the reography. The authors underline the increased activity of both fibroblasts and osteoblasts as pathogenetic clue of the hypertrophic dermo-osteopathy.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number10
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Pachydermoperiostosis. Ultrastructural and vascular observations'. Together they form a unique fingerprint.

  • Cite this

    Nini, G., Calvieri, S., Gatti, S., Lupini, S., Bianchi, L., Di Carlo, A., Carrozzo, A. M., Iraci, S., & Marinaro, C. (1988). Pachydermoperiostosis. Ultrastructural and vascular observations. Giornale Italiano di Dermatologia e Venereologia, 123(10), 481-487.