Paclitaxel, vinorelbine and 5-fluorouracil in breast cancer patients pretreated with adjuvant anthracyclines

A. Berruti, R. Bitossi, G. Gorzegno, A. Bottini, D. Generali, M. Milani, D. Katsaros, I. A. Rigault De La Longrais, R. Bellino, M. Donadio, M. Ardine, O. Bertetto, S. Danese, M. G. Sarobba, A. Farris, V. Lorusso, L. Dogliotti

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the activity and toxicity of a combination of vinorelbine (VNB), paclitaxel (PTX) and 5-fluorouracil (5-FU) continuous infusion administered as first-line chemotherapy in metastatic breast cancer patients pretreated with adjuvant anthracyclines. A total of 61 patients received a regimen consisting of VNB 25 mg m-2 on days 1 and 15, PTX 60 mg m-2 on days 1, 8 and 15 and continuous infusion of 5-FU at 200 mg m-2 every day. Cycles were repeated every 28 days. Disease response was evaluated by both RECIST and World Health Organization (WHO) criteria. Objective responses were recorded in 39 of 61 patients (64.0%) assessed by WHO and in 36 of 50 patients (72.0%) assessable by RECIST criteria. Complete remission occurred in 15 (24.6%) and 14 patients (28.0%), respectively. The median time to progression and overall survival of entire population was 10.6 and 27.3 months, respectively, and median duration of complete response was 14.8 months. The dose-limiting toxicity was myelosuppression (leucopenia grade 3/4 in 52.5% of patients). Grade 3/4 nonhaematologic toxicities included mucositis/diarrhoea in 13.1%, skin in 3.3% and cardiac in 1.6% of patients. Grade 2/3 neurotoxicity was observed in five patients (7.2%). The VNB, PTX and 5-FU continuous infusion combination regimen was active and manageable. Complete responses were frequent and durable.

Original languageEnglish
Pages (from-to)634-638
Number of pages5
JournalBritish Journal of Cancer
Volume92
Issue number4
DOIs
Publication statusPublished - Feb 28 2005

Keywords

  • 5-fluorouracil
  • Breast cancer
  • Metastatic disease
  • Paclitaxel
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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