Paediatric-onset systemic lupus erythematosus

Research output: Contribution to journalArticle

Abstract

Paediatric-onset systemic lupus erythematosus (SLE) is usually more severe than its adult counterpart. In particular, there is a higher incidence of renal and central nervous system involvement. Specific measures to assess disease activity and damage have been implemented. The disease is very rare before the fifth birthday and therefore the onset of an SLE picture in the first years of life should lead to the suspicion of the presence of one of the rare monogenic diseases that causes SLE or of one of those congenital diseases that has been showed to be closely associated with the SLE.

Original languageEnglish
JournalBest Practice and Research: Clinical Rheumatology
DOIs
Publication statusAccepted/In press - 2013

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Systemic Lupus Erythematosus
Pediatrics
Rare Diseases
Central Nervous System
Kidney
Incidence

Keywords

  • Juvenile SLE
  • Monogenic SLE
  • Paediatric-onset SLE
  • SLE-associated genetic diseases

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "Paediatric-onset systemic lupus erythematosus",
abstract = "Paediatric-onset systemic lupus erythematosus (SLE) is usually more severe than its adult counterpart. In particular, there is a higher incidence of renal and central nervous system involvement. Specific measures to assess disease activity and damage have been implemented. The disease is very rare before the fifth birthday and therefore the onset of an SLE picture in the first years of life should lead to the suspicion of the presence of one of the rare monogenic diseases that causes SLE or of one of those congenital diseases that has been showed to be closely associated with the SLE.",
keywords = "Juvenile SLE, Monogenic SLE, Paediatric-onset SLE, SLE-associated genetic diseases",
author = "Clara Malattia and Alberto Martini",
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language = "English",
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AU - Martini, Alberto

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AB - Paediatric-onset systemic lupus erythematosus (SLE) is usually more severe than its adult counterpart. In particular, there is a higher incidence of renal and central nervous system involvement. Specific measures to assess disease activity and damage have been implemented. The disease is very rare before the fifth birthday and therefore the onset of an SLE picture in the first years of life should lead to the suspicion of the presence of one of the rare monogenic diseases that causes SLE or of one of those congenital diseases that has been showed to be closely associated with the SLE.

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KW - Monogenic SLE

KW - Paediatric-onset SLE

KW - SLE-associated genetic diseases

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