Esposizione a IPA, 1-idrossipirene urinario e addotti al DNA in campioni di popolazione residenti a diversa distanza da un polo siderurgico

Translated title of the contribution: PAHs exposure, urinary 1-pyrenol and DNA adducts among populations living at different distance from an Italian steel plant

G. M. Ferri, A. Gallo, M. Sumerano, M. R. De Nicoli, A. Izzotti, M. Conversano, F. Bailardi, G. Antonelli, R. Crescenzo, V. Ricci, F. Cassano, G. DeMarinis, G. Elia, V. Corrado, A. Lo Izzo, G. De Nichilo, A. Ferranini, G. Assennato

Research output: Contribution to journalArticlepeer-review

Abstract

This study aims at measuring association between environmental exposure to PAHs and internal or biologically effective dose biomarkers among 212 individuals living at different distance from the industrial area of Taranto, Italy. Environmental PAH exposure was determined by area monitoring. PAH levels was measured by HPLC UV/FL. Urinary 1-hydroxypyrene levels were measured by HPLC/Fluorescence. The levels of DNA adducts were determined by 32P-postlabelling. A questionnaire was administered to gather personal data, residence, occupational history, alcohol, tobacco smoke, and diet, to control for other sources of exposure to PAH. Blood and urinary samples, drawn from the subjects studied were collected and analysed. A multivariate regression model was used to investigate the influence of several confounding factors. Housing was placed within 1 km from smokestacks in Taranto and Statte, whereas they were more far away in Locorotondo and in Alberobello. The prevalence of current smokers was 31.6%.

Translated title of the contributionPAHs exposure, urinary 1-pyrenol and DNA adducts among populations living at different distance from an Italian steel plant
Original languageItalian
Pages (from-to)32-34
Number of pages3
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume25
Issue numberSUPPL. 3
Publication statusPublished - Jul 2003

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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