PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis

Filippo Aucella, Maurizio Margaglione, Mimmo Vigilante, Giuseppe Gatta, Elvira Grandone, Mauro Forcella, Maria Ktena, Alva De Min, Giovanna Salatino, Deni Aldo Procacinni, Carmine Stallone

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background. Myocardial infarction (MI) is a leading cause of death, particularly in high-risk settings such as uraemia, in which it is not yet known to what extent genetic factors contribute to the overall risk of MI. We have prospectively evaluated the effect of plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the occurrence of MI in uraemics. Methods. All patients undergoing intermittent dialysis in an Italian district were enrolled as subjects. From the same area, 1307 individuals served as controls. Genomic DNA was obtained and ACE I/D and PAI-1 4G/5G gene polymorphisms were determined. After a baseline evaluation, patients were followed for 28.8± 9.8 months. MIs and other causes of death were recorded. Results. A total of 461 patients (417 on haemodialysis and 44 on peritoneal dialysis) were investigated. At entry, their mean age was 58.2±16.2 years and dialytic age was 82±69 months. Genotype frequencies were not different between controls and uraemics and, in the latter group, between patients with or without cardiovascular diseases at baseline evaluation. During the follow-up, 22 fatal and 16 non-fatal MIs were recorded (mean incidence 1.99 and 1.45%/year, respectively). The adjusted risk of fatal and total MI was related to the presence at entry of a history of MI [hazard ratios (HR) 4.3; 95% confidence interval (CI) 1.5-12.0 and HR 6.8; 95% CI: 3.3-14.0, respectively] and to the PAI-1 4/4 genotype (HR 2.8; 95% CI 1.2-6.9 and HR 2.1; 95% CI 1.1-4.2, respectively). Conclusions. In end-stage renal disease, PAI-1 4G/5G gene polymorphism may have a significant role in the occurrence of fatal and non-fatal MI.

Original languageEnglish
Pages (from-to)1142-1146
Number of pages5
JournalNephrology Dialysis Transplantation
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Insertional Mutagenesis
Plasminogen Activator Inhibitor 1
Gene Deletion
Peptidyl-Dipeptidase A
Dialysis
Myocardial Infarction
Confidence Intervals
Cause of Death
Genotype
Uremia
Peritoneal Dialysis
Genes
Chronic Kidney Failure
Renal Dialysis
Cardiovascular Diseases
DNA
Incidence

Keywords

  • ACE
  • Dialysis
  • Genetics
  • Mortality
  • Myocardial infarction
  • PAI-1

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis. / Aucella, Filippo; Margaglione, Maurizio; Vigilante, Mimmo; Gatta, Giuseppe; Grandone, Elvira; Forcella, Mauro; Ktena, Maria; De Min, Alva; Salatino, Giovanna; Procacinni, Deni Aldo; Stallone, Carmine.

In: Nephrology Dialysis Transplantation, Vol. 18, No. 6, 01.06.2003, p. 1142-1146.

Research output: Contribution to journalArticle

Aucella, F, Margaglione, M, Vigilante, M, Gatta, G, Grandone, E, Forcella, M, Ktena, M, De Min, A, Salatino, G, Procacinni, DA & Stallone, C 2003, 'PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis', Nephrology Dialysis Transplantation, vol. 18, no. 6, pp. 1142-1146. https://doi.org/10.1093/ndt/gfg118
Aucella, Filippo ; Margaglione, Maurizio ; Vigilante, Mimmo ; Gatta, Giuseppe ; Grandone, Elvira ; Forcella, Mauro ; Ktena, Maria ; De Min, Alva ; Salatino, Giovanna ; Procacinni, Deni Aldo ; Stallone, Carmine. / PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis. In: Nephrology Dialysis Transplantation. 2003 ; Vol. 18, No. 6. pp. 1142-1146.
@article{7bf7bfcea3fa405693f580d59e7152b2,
title = "PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis",
abstract = "Background. Myocardial infarction (MI) is a leading cause of death, particularly in high-risk settings such as uraemia, in which it is not yet known to what extent genetic factors contribute to the overall risk of MI. We have prospectively evaluated the effect of plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the occurrence of MI in uraemics. Methods. All patients undergoing intermittent dialysis in an Italian district were enrolled as subjects. From the same area, 1307 individuals served as controls. Genomic DNA was obtained and ACE I/D and PAI-1 4G/5G gene polymorphisms were determined. After a baseline evaluation, patients were followed for 28.8± 9.8 months. MIs and other causes of death were recorded. Results. A total of 461 patients (417 on haemodialysis and 44 on peritoneal dialysis) were investigated. At entry, their mean age was 58.2±16.2 years and dialytic age was 82±69 months. Genotype frequencies were not different between controls and uraemics and, in the latter group, between patients with or without cardiovascular diseases at baseline evaluation. During the follow-up, 22 fatal and 16 non-fatal MIs were recorded (mean incidence 1.99 and 1.45{\%}/year, respectively). The adjusted risk of fatal and total MI was related to the presence at entry of a history of MI [hazard ratios (HR) 4.3; 95{\%} confidence interval (CI) 1.5-12.0 and HR 6.8; 95{\%} CI: 3.3-14.0, respectively] and to the PAI-1 4/4 genotype (HR 2.8; 95{\%} CI 1.2-6.9 and HR 2.1; 95{\%} CI 1.1-4.2, respectively). Conclusions. In end-stage renal disease, PAI-1 4G/5G gene polymorphism may have a significant role in the occurrence of fatal and non-fatal MI.",
keywords = "ACE, Dialysis, Genetics, Mortality, Myocardial infarction, PAI-1",
author = "Filippo Aucella and Maurizio Margaglione and Mimmo Vigilante and Giuseppe Gatta and Elvira Grandone and Mauro Forcella and Maria Ktena and {De Min}, Alva and Giovanna Salatino and Procacinni, {Deni Aldo} and Carmine Stallone",
year = "2003",
month = "6",
day = "1",
doi = "10.1093/ndt/gfg118",
language = "English",
volume = "18",
pages = "1142--1146",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis

AU - Aucella, Filippo

AU - Margaglione, Maurizio

AU - Vigilante, Mimmo

AU - Gatta, Giuseppe

AU - Grandone, Elvira

AU - Forcella, Mauro

AU - Ktena, Maria

AU - De Min, Alva

AU - Salatino, Giovanna

AU - Procacinni, Deni Aldo

AU - Stallone, Carmine

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Background. Myocardial infarction (MI) is a leading cause of death, particularly in high-risk settings such as uraemia, in which it is not yet known to what extent genetic factors contribute to the overall risk of MI. We have prospectively evaluated the effect of plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the occurrence of MI in uraemics. Methods. All patients undergoing intermittent dialysis in an Italian district were enrolled as subjects. From the same area, 1307 individuals served as controls. Genomic DNA was obtained and ACE I/D and PAI-1 4G/5G gene polymorphisms were determined. After a baseline evaluation, patients were followed for 28.8± 9.8 months. MIs and other causes of death were recorded. Results. A total of 461 patients (417 on haemodialysis and 44 on peritoneal dialysis) were investigated. At entry, their mean age was 58.2±16.2 years and dialytic age was 82±69 months. Genotype frequencies were not different between controls and uraemics and, in the latter group, between patients with or without cardiovascular diseases at baseline evaluation. During the follow-up, 22 fatal and 16 non-fatal MIs were recorded (mean incidence 1.99 and 1.45%/year, respectively). The adjusted risk of fatal and total MI was related to the presence at entry of a history of MI [hazard ratios (HR) 4.3; 95% confidence interval (CI) 1.5-12.0 and HR 6.8; 95% CI: 3.3-14.0, respectively] and to the PAI-1 4/4 genotype (HR 2.8; 95% CI 1.2-6.9 and HR 2.1; 95% CI 1.1-4.2, respectively). Conclusions. In end-stage renal disease, PAI-1 4G/5G gene polymorphism may have a significant role in the occurrence of fatal and non-fatal MI.

AB - Background. Myocardial infarction (MI) is a leading cause of death, particularly in high-risk settings such as uraemia, in which it is not yet known to what extent genetic factors contribute to the overall risk of MI. We have prospectively evaluated the effect of plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the occurrence of MI in uraemics. Methods. All patients undergoing intermittent dialysis in an Italian district were enrolled as subjects. From the same area, 1307 individuals served as controls. Genomic DNA was obtained and ACE I/D and PAI-1 4G/5G gene polymorphisms were determined. After a baseline evaluation, patients were followed for 28.8± 9.8 months. MIs and other causes of death were recorded. Results. A total of 461 patients (417 on haemodialysis and 44 on peritoneal dialysis) were investigated. At entry, their mean age was 58.2±16.2 years and dialytic age was 82±69 months. Genotype frequencies were not different between controls and uraemics and, in the latter group, between patients with or without cardiovascular diseases at baseline evaluation. During the follow-up, 22 fatal and 16 non-fatal MIs were recorded (mean incidence 1.99 and 1.45%/year, respectively). The adjusted risk of fatal and total MI was related to the presence at entry of a history of MI [hazard ratios (HR) 4.3; 95% confidence interval (CI) 1.5-12.0 and HR 6.8; 95% CI: 3.3-14.0, respectively] and to the PAI-1 4/4 genotype (HR 2.8; 95% CI 1.2-6.9 and HR 2.1; 95% CI 1.1-4.2, respectively). Conclusions. In end-stage renal disease, PAI-1 4G/5G gene polymorphism may have a significant role in the occurrence of fatal and non-fatal MI.

KW - ACE

KW - Dialysis

KW - Genetics

KW - Mortality

KW - Myocardial infarction

KW - PAI-1

UR - http://www.scopus.com/inward/record.url?scp=0037670184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037670184&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfg118

DO - 10.1093/ndt/gfg118

M3 - Article

C2 - 12748347

AN - SCOPUS:0037670184

VL - 18

SP - 1142

EP - 1146

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 6

ER -