PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: Relation to environmental and genetic determinants

Maurizio Margaglione, Giuseppe Cappucci, Marina D'Addedda, Donatella Colaizzo, Nicola Giuliani, Gennaro Vecchione, Giulio Mascolo, Elvira Grandone, Giovanni Di Minno

Research output: Contribution to journalArticlepeer-review

Abstract

Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. The renin- angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. None of the individuals enrolled had clinical evidence of atherosclerosis. In univariate analysis, PAI-1 levels were significantly higher in men (P

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume18
Issue number4
Publication statusPublished - 1998

Keywords

  • Angiotensin- converting enzyme
  • Fibrinolytic activity
  • Gene variant
  • Plasminogen activator inhibitor 1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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