PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis

Rosa Divella, Rosanna Lacalamita, Stefania Tommasi, Maria Coviello, Antonella Daniele, Vito Michele Garrisi, Ines Abbate, Giovanni Simone, Cosimo Gadaleta, Angelo Paradiso, Michele Quaranta

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfafetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalAnticancer Research
Volume28
Issue number1 A
Publication statusPublished - Jan 2008

Fingerprint

Plasminogen Activator Inhibitor 1
Tissue Plasminogen Activator
Virus Diseases
Carcinogenesis
Liver
DNA
Telomerase
Hepatitis C
Hepatitis B
Real-Time Polymerase Chain Reaction
Hepatocellular Carcinoma
Viruses
Control Groups
Enzymes
Infection

Keywords

  • Circulating hTERT DNA
  • Hepatocellular carcinoma
  • PAI-1
  • t-PA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Divella, R., Lacalamita, R., Tommasi, S., Coviello, M., Daniele, A., Garrisi, V. M., ... Quaranta, M. (2008). PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis. Anticancer Research, 28(1 A), 223-228.

PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis. / Divella, Rosa; Lacalamita, Rosanna; Tommasi, Stefania; Coviello, Maria; Daniele, Antonella; Garrisi, Vito Michele; Abbate, Ines; Simone, Giovanni; Gadaleta, Cosimo; Paradiso, Angelo; Quaranta, Michele.

In: Anticancer Research, Vol. 28, No. 1 A, 01.2008, p. 223-228.

Research output: Contribution to journalArticle

@article{bfaaea766ca540c988e28b95e96cb6b2,
title = "PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis",
abstract = "Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfafetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p",
keywords = "Circulating hTERT DNA, Hepatocellular carcinoma, PAI-1, t-PA",
author = "Rosa Divella and Rosanna Lacalamita and Stefania Tommasi and Maria Coviello and Antonella Daniele and Garrisi, {Vito Michele} and Ines Abbate and Giovanni Simone and Cosimo Gadaleta and Angelo Paradiso and Michele Quaranta",
year = "2008",
month = "1",
language = "English",
volume = "28",
pages = "223--228",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1 A",

}

TY - JOUR

T1 - PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis

AU - Divella, Rosa

AU - Lacalamita, Rosanna

AU - Tommasi, Stefania

AU - Coviello, Maria

AU - Daniele, Antonella

AU - Garrisi, Vito Michele

AU - Abbate, Ines

AU - Simone, Giovanni

AU - Gadaleta, Cosimo

AU - Paradiso, Angelo

AU - Quaranta, Michele

PY - 2008/1

Y1 - 2008/1

N2 - Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfafetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p

AB - Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfafetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p

KW - Circulating hTERT DNA

KW - Hepatocellular carcinoma

KW - PAI-1

KW - t-PA

UR - http://www.scopus.com/inward/record.url?scp=40549120297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549120297&partnerID=8YFLogxK

M3 - Article

C2 - 18383849

AN - SCOPUS:40549120297

VL - 28

SP - 223

EP - 228

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1 A

ER -