PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis

Rosa Divella, Rosanna Lacalamita, Stefania Tommasi, Maria Coviello, Antonella Daniele, Vito Michele Garrisi, Ines Abbate, Giovanni Simone, Cosimo Gadaleta, Angelo Paradiso, Michele Quaranta

Research output: Contribution to journalArticle

Abstract

Background: Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfafetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. Patients and Methods: A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). Results: PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalAnticancer Research
Volume28
Issue number1 A
Publication statusPublished - Jan 2008

Keywords

  • Circulating hTERT DNA
  • Hepatocellular carcinoma
  • PAI-1
  • t-PA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Divella, R., Lacalamita, R., Tommasi, S., Coviello, M., Daniele, A., Garrisi, V. M., Abbate, I., Simone, G., Gadaleta, C., Paradiso, A., & Quaranta, M. (2008). PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis. Anticancer Research, 28(1 A), 223-228.