Pain and thyroid hormones

Anna Maria Aloisi, Stella Vodo, Michelangelo Buonocore

Research output: Contribution to journalArticlepeer-review


The role of endocrine systems in chronic pain mechanisms is slowly getting increasing experimental and clinical consideration. Many painful conditions appear to be directly and/or indirectly induced, reduced or, in some cases, modulated by hormones. We have done much work in trying to understand the relationship between hormones and pain, with particular attention to the hypothalamus-pituitary-gonadal axis. To expand our knowledge of this field, we have directed our attention to another axis, the hypothalamus-pituitary-thyroid (HPT). The literature on thyroid functions is vast but very few studies have focused on the HPT axis and pain. The few available data are considered in the present review to stimulate interest in the possible interactions between the HPT axis and pain.

Original languageEnglish
Pages (from-to)1501-1508
Number of pages8
JournalNeurological Sciences
Issue number9
Publication statusPublished - Sep 2013


  • Inflammation
  • Neuropathic pain
  • Pain
  • Sex differences
  • Thyroid

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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