Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment

Luigina Guasti, Franca Marino, Marco Cosentino, Mariagrazia Cimpanelli, Emanuela Rasini, Eliana Piantanida, Paolo Vanoli, Diego De Palma, Chiara Crespi, Catherine Klersy, Lorenzo Maroni, Anna Loraschi, Cristina Colombo, Cinzia Simoni, Luigi Bartalena, Sergio Lecchini, Anna M. Grandi, Achille Venco

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Elevated blood pressure levels that are associated with hypalgesia and hypothyroidism have major influences on the cardiovascular system. The potential modulation of pain sensitivity by thyroid hormones is largely undetermined. Moreover, a few experimental studies show that peripheral benzodiazepine receptors (PBRs), which may be altered in hypothyroidism, seem to be related with pain perception. METHODS: Dental pain threshold and tolerance were evaluated in 19 patients followed for differentiated thyroid carcinoma (1) in severe short-term hypothyroidism (phase 1) and (2) during thyroid stimulating hormone-suppressive LT4 treatment (phase 2). PBR expression (cytofluorimetric evaluation) on peripheral blood mononuclear cells was also investigated in the 2 phases. RESULTS: Pain perception differed throughout the study, the dental pain threshold was higher in phase 1 (P

Original languageEnglish
Pages (from-to)518-523
Number of pages6
JournalClinical Journal of Pain
Volume23
Issue number6
DOIs
Publication statusPublished - Jul 2007

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Keywords

  • Blood pressure
  • Hypothyroidism
  • Pain perception

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Guasti, L., Marino, F., Cosentino, M., Cimpanelli, M., Rasini, E., Piantanida, E., Vanoli, P., De Palma, D., Crespi, C., Klersy, C., Maroni, L., Loraschi, A., Colombo, C., Simoni, C., Bartalena, L., Lecchini, S., Grandi, A. M., & Venco, A. (2007). Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment. Clinical Journal of Pain, 23(6), 518-523. https://doi.org/10.1097/AJP.0b013e3180735e5e