Abstract
BACKGROUND: Elevated blood pressure levels that are associated with hypalgesia and hypothyroidism have major influences on the cardiovascular system. The potential modulation of pain sensitivity by thyroid hormones is largely undetermined. Moreover, a few experimental studies show that peripheral benzodiazepine receptors (PBRs), which may be altered in hypothyroidism, seem to be related with pain perception. METHODS: Dental pain threshold and tolerance were evaluated in 19 patients followed for differentiated thyroid carcinoma (1) in severe short-term hypothyroidism (phase 1) and (2) during thyroid stimulating hormone-suppressive LT4 treatment (phase 2). PBR expression (cytofluorimetric evaluation) on peripheral blood mononuclear cells was also investigated in the 2 phases. RESULTS: Pain perception differed throughout the study, the dental pain threshold was higher in phase 1 (P
Original language | English |
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Pages (from-to) | 518-523 |
Number of pages | 6 |
Journal | Clinical Journal of Pain |
Volume | 23 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jul 2007 |
Keywords
- Blood pressure
- Hypothyroidism
- Pain perception
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Clinical Neurology