Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment

Luigina Guasti; Franca Marino; Marco Cosentino; Mariagrazia Cimpanelli; Emanuela Rasini; Eliana Piantanida; Paolo Vanoli; Diego De Palma; Chiara Crespi; Catherine Klersy; Lorenzo Maroni; Anna Loraschi; Cristina Colombo; Cinzia Simoni; Luigi Bartalena; Sergio Lecchini; Anna M. Grandi; Achille Venco

doi:10.1097/AJP.0b013e3180735e5e

Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment

Luigina Guasti, Franca Marino, Marco Cosentino, Mariagrazia Cimpanelli, Emanuela Rasini, Eliana Piantanida, Paolo Vanoli, Diego De Palma, Chiara Crespi, Catherine Klersy, Lorenzo Maroni, Anna Loraschi, Cristina Colombo, Cinzia Simoni, Luigi Bartalena, Sergio Lecchini, Anna M. Grandi, Achille Venco

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Elevated blood pressure levels that are associated with hypalgesia and hypothyroidism have major influences on the cardiovascular system. The potential modulation of pain sensitivity by thyroid hormones is largely undetermined. Moreover, a few experimental studies show that peripheral benzodiazepine receptors (PBRs), which may be altered in hypothyroidism, seem to be related with pain perception. METHODS: Dental pain threshold and tolerance were evaluated in 19 patients followed for differentiated thyroid carcinoma (1) in severe short-term hypothyroidism (phase 1) and (2) during thyroid stimulating hormone-suppressive LT4 treatment (phase 2). PBR expression (cytofluorimetric evaluation) on peripheral blood mononuclear cells was also investigated in the 2 phases. RESULTS: Pain perception differed throughout the study, the dental pain threshold was higher in phase 1 (P

Original language	English
Pages (from-to)	518-523
Number of pages	6
Journal	Clinical Journal of Pain
Volume	23
Issue number	6
DOIs	https://doi.org/10.1097/AJP.0b013e3180735e5e
Publication status	Published - Jul 2007

Keywords

Blood pressure
Hypothyroidism
Pain perception

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Clinical Neurology

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Guasti, L., Marino, F., Cosentino, M., Cimpanelli, M., Rasini, E., Piantanida, E., Vanoli, P., De Palma, D., Crespi, C., Klersy, C., Maroni, L., Loraschi, A., Colombo, C., Simoni, C., Bartalena, L., Lecchini, S., Grandi, A. M., & Venco, A. (2007). Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment. Clinical Journal of Pain, 23(6), 518-523. https://doi.org/10.1097/AJP.0b013e3180735e5e

Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma : A longitudinal study in hypothyroidism and during hormone treatment. / Guasti, Luigina; Marino, Franca; Cosentino, Marco; Cimpanelli, Mariagrazia; Rasini, Emanuela; Piantanida, Eliana; Vanoli, Paolo; De Palma, Diego; Crespi, Chiara; Klersy, Catherine; Maroni, Lorenzo; Loraschi, Anna; Colombo, Cristina; Simoni, Cinzia; Bartalena, Luigi; Lecchini, Sergio; Grandi, Anna M.; Venco, Achille.

In: Clinical Journal of Pain, Vol. 23, No. 6, 07.2007, p. 518-523.

Research output: Contribution to journal › Article › peer-review

Guasti, L, Marino, F, Cosentino, M, Cimpanelli, M, Rasini, E, Piantanida, E, Vanoli, P, De Palma, D, Crespi, C, Klersy, C, Maroni, L, Loraschi, A, Colombo, C, Simoni, C, Bartalena, L, Lecchini, S, Grandi, AM & Venco, A 2007, 'Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment', Clinical Journal of Pain, vol. 23, no. 6, pp. 518-523. https://doi.org/10.1097/AJP.0b013e3180735e5e

Guasti L, Marino F, Cosentino M, Cimpanelli M, Rasini E, Piantanida E et al. Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment. Clinical Journal of Pain. 2007 Jul;23(6):518-523. https://doi.org/10.1097/AJP.0b013e3180735e5e

Guasti, Luigina ; Marino, Franca ; Cosentino, Marco ; Cimpanelli, Mariagrazia ; Rasini, Emanuela ; Piantanida, Eliana ; Vanoli, Paolo ; De Palma, Diego ; Crespi, Chiara ; Klersy, Catherine ; Maroni, Lorenzo ; Loraschi, Anna ; Colombo, Cristina ; Simoni, Cinzia ; Bartalena, Luigi ; Lecchini, Sergio ; Grandi, Anna M. ; Venco, Achille. / Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma : A longitudinal study in hypothyroidism and during hormone treatment. In: Clinical Journal of Pain. 2007 ; Vol. 23, No. 6. pp. 518-523.

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abstract = "BACKGROUND: Elevated blood pressure levels that are associated with hypalgesia and hypothyroidism have major influences on the cardiovascular system. The potential modulation of pain sensitivity by thyroid hormones is largely undetermined. Moreover, a few experimental studies show that peripheral benzodiazepine receptors (PBRs), which may be altered in hypothyroidism, seem to be related with pain perception. METHODS: Dental pain threshold and tolerance were evaluated in 19 patients followed for differentiated thyroid carcinoma (1) in severe short-term hypothyroidism (phase 1) and (2) during thyroid stimulating hormone-suppressive LT4 treatment (phase 2). PBR expression (cytofluorimetric evaluation) on peripheral blood mononuclear cells was also investigated in the 2 phases. RESULTS: Pain perception differed throughout the study, the dental pain threshold was higher in phase 1 (P",

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author = "Luigina Guasti and Franca Marino and Marco Cosentino and Mariagrazia Cimpanelli and Emanuela Rasini and Eliana Piantanida and Paolo Vanoli and {De Palma}, Diego and Chiara Crespi and Catherine Klersy and Lorenzo Maroni and Anna Loraschi and Cristina Colombo and Cinzia Simoni and Luigi Bartalena and Sergio Lecchini and Grandi, {Anna M.} and Achille Venco",

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AU - Cosentino, Marco

AU - Cimpanelli, Mariagrazia

AU - Rasini, Emanuela

AU - Piantanida, Eliana

AU - Vanoli, Paolo

AU - De Palma, Diego

AU - Crespi, Chiara

AU - Klersy, Catherine

AU - Maroni, Lorenzo

AU - Loraschi, Anna

AU - Colombo, Cristina

AU - Simoni, Cinzia

AU - Bartalena, Luigi

AU - Lecchini, Sergio

AU - Grandi, Anna M.

AU - Venco, Achille

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Pain perception, blood pressure levels, and peripheral benzodiazepine receptors in patients followed for differentiated thyroid carcinoma: A longitudinal study in hypothyroidism and during hormone treatment

Abstract

Keywords

ASJC Scopus subject areas

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