Pain perception following epithelialized gingival graft harvesting: a randomized clinical trial

Lorenzo Tavelli, Andrea Ravidà, Muhammad H.A. Saleh, Bartosz Maska, Fernando Suárez López del Amo, Giulio Rasperini, Hom Lay Wang

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting. Material and methods: The present study consisted of 44 EGGs harvested in 44 patients. In the control group, a hemostatic collagen sponge was applied over the palatal wound, while the test group was treated with additional cyanoacrylate. Patients were observed for 14 days, evaluating the pain level by using the visual analogic scale. The consumption of analgesic during the postoperative period, the willingness for retreatment and the characteristic of the graft were also analyzed. Results: Statistically significant differences in pain perception were found between test and control groups in each of the studied days (p < 0.01). Analgesic consumption was lower in the test group (p < 0.01). Graft width < 14 mm was found to be associated with lower discomfort (p < 0.01). Conclusions: Adding an additional layer of cyanoacrylate over a hemostatic collagen sponge on the palatal wound following EGG harvesting was found to be successful in minimizing the postoperative discomfort and the need for analgesics. Clinical relevance: Postoperative pain after palatal tissue harvesting can be successfully minimized if the donor site open wound is protected with an external layer of cyanoacrylate over a collagen sponge.

Original languageEnglish
Pages (from-to)459-468
Number of pages10
JournalClinical Oral Investigations
Issue number1
Publication statusPublished - Jan 29 2019
Externally publishedYes


  • Autografts
  • Free soft tissue graft
  • Pain management
  • Wound healing

ASJC Scopus subject areas

  • Dentistry(all)

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