Painful neuropathy in subclinical hypothyroidism: Clinical and neuropathological recovery after hormone replacement therapy

Paola Penza, Raffaella Lombardi, Francesca Camozzi, Claudia Ciano, Giuseppe Lauria

Research output: Contribution to journalArticle

Abstract

We describe a 60-year-old woman complaining of severe burning feet for 3 months. A neurological examination showed absent Achilles tendon reflexes; nerve conduction study demonstrated mild sensory neuropathy, and skin biopsy revealed a length-dependent loss of intraepidermal nerve fibres. Haematological exams demonstrated a subclinical hypothyroidism and hormone replacement therapy was started. Conversely, symptomatic treatments for neuropathic pain were withdrawn after few days because of side effects. During the following months, thyroid function recovered, and the patient experienced a progressive decrease of neuropathic pain intensity. At 6- and 12-month follow-ups, nerve conduction study and clinical examination were normal, whereas skin biopsy demonstrated a complete reinnervation of the epidermis. Subclinical hypothyroidism is a possible cause of sensory neuropathy and hormone replacement therapy can prompt nerve regeneration.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalNeurological Sciences
Volume30
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Neural Conduction
Hormone Replacement Therapy
Neuralgia
Hypothyroidism
Biopsy
Stretch Reflex
Skin
Nerve Regeneration
Achilles Tendon
Neurologic Examination
Nerve Fibers
Epidermis
Foot
Thyroid Gland
Painful Neuropathy
Therapeutics
Clinical Studies

Keywords

  • Nerve conduction study
  • Nerve regeneration
  • Painful neuropathy
  • Skin biopsy
  • Thyroid

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

Painful neuropathy in subclinical hypothyroidism : Clinical and neuropathological recovery after hormone replacement therapy. / Penza, Paola; Lombardi, Raffaella; Camozzi, Francesca; Ciano, Claudia; Lauria, Giuseppe.

In: Neurological Sciences, Vol. 30, No. 2, 2009, p. 149-151.

Research output: Contribution to journalArticle

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