Palatability of crushed β-blockers, converting enzyme inhibitors and thiazides

L. Zgraggen, P. B. Faré, S. A G Lava, G. D. Simonetti, E. F. Fossali, C. Amoruso, M. G. Bianchetti

Research output: Contribution to journalArticle

Abstract

What is known and Objectives: A problem that often affects antihypertensive drugs is the lack of formulations appropriate for childhood. Parents, therefore, crush tablets and administer the antihypertensive drug mixed with solid food or a palatable drink. Because palatability is a major modulator of adherence to prescribed medication, the palatability of crushed β-blockers, converting enzyme inhibitors and thiazides was assessed among adult volunteers. Methods: The palatability of crushed atenolol, bisoprolol, enalapril, lisinopril, ramipril, chlorthalidone and hydrochlorothiazide was evaluated by means of a facial hedonic scale among 20 volunteers. The calcium channel-blockers amlodipine and lercanidipine whose tastes are disliked and liked, respectively, by children were also tested. A concealed random allocation procedure was used. Results: The palatability scores assigned to chlorthalidone, hydrochlorothiazide and lisinopril were superior (P <0.002) to those assigned to atenolol, bisoprolol, enalapril and ramipril. As with children, the palatability score of lercanidipine was superior to that of amlodipine (P <0.002). The scores assigned to the various agents were similar in women and in men and were age-independent. What is new and Conclusion: Pulverized atenolol, bisoprolol, enalapril and ramipril are poor tasting. From the perspective of palatability, pulverized chlorthalidone, hydrochlorothiazide and lisinopril are preferable.

Original languageEnglish
Pages (from-to)544-546
Number of pages3
JournalJournal of Clinical Pharmacy and Therapeutics
Volume37
Issue number5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • β-blockers
  • converting enzyme inhibitors
  • crushed drugs
  • palatability
  • thiazides

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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