Palinopsia in patients with migraine: A case-control study

Vincenzo Belcastro, Letizia Maria Cupini, Ilenia Corbelli, Alessio Pieroni, Cataldo D'Amore, Stefano Caproni, Gaetano Gorgone, Edoardo Ferlazzo, Franco Di Palma, Paola Sarchielli, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review


Objectives: This study was aimed at investigating the frequency of the visual phenomenon of palinopsia (visual perseveration) in patients with migraine.Methods: We interviewed 63 patients with migraine with aura (MwA), 137 patients with migraine without aura (MwoA) and 226 sex-age-matched healthy control subjects using an ad hoc structured interview/questionnaire. The interview was divided into four classes of variables for statistical testing.Results: Palinopsia occurred in 19/200 patients (9.5%); of them 10/63 had MwA and 9/137 MwoA (14.2% vs 6.6%, chi = 9.7, degrees of freedom = 1, p = 0.002). Patients with palinopsia had a significantly lower migraine attack frequency than those without this visual phenomenon (4.3 ± 0.3 vs 14.4 ± 0.2, z = 7.1, p <0.0001). No healthy control subjects complained of palinopsia according to the structured interview/questionnaire.Discussion: Palinopsia is probably under-diagnosed in patients with migraine. Further investigations are needed to assess whether migraineurs are particularly susceptible to the development of recurrent episodes of visual perseveration.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
Issue number9
Publication statusPublished - Jul 2011


  • aura
  • migraine
  • Palinopsia
  • visual hallucinations

ASJC Scopus subject areas

  • Clinical Neurology


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