Paliperidone palmitate depot in the long-term treatment of psychotic bipolar disorder: A case series

Massimiliano Buoli, Valentina Ciappolino, Alfredo Carlo Altamura

Research output: Contribution to journalArticlepeer-review


Objectives: The treatment of bipolar disorder (BD) cannot be limited to the remission of acute phases but includes the long-term treatment in order to prevent relapses, poor outcome, and chronicity. The purpose of this article is to present 3 cases of severe psychotic bipolar patients treated with monthly injection of paliperidone pamoate. Methods: Three poor-compliant severe psychotic BD patients were initiated to paliperidone palmitate (100-150 mg monthly), and they were followed up for 12 months. Young Mania Rating Scale and Hamilton Depression Rating Scale were administered at baseline and during monthly follow-up visits. Results: None of patients presented recurrences or relapses during the 12-month follow-up period. The patients did not develop adverse effects or significant changes in metabolism. Conclusions: These preliminary results indicate that paliperidone palmitate (100-150mgmonthly)may be a therapeutic option for long-term treatment of psychotic BD, particularly for poor-compliant severe patients. These results have to be confirmed in double-blind studies with bipolar patients not necessarily belonging to psychotic subtype.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalClinical Neuropharmacology
Issue number5
Publication statusPublished - Oct 1 2015


  • Long-term treatment
  • Paliperidone palmitate
  • Psychotic bipolar disorder

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Clinical Neurology


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