TY - JOUR
T1 - Paliperidone palmitate depot in the long-term treatment of psychotic bipolar disorder
T2 - A case series
AU - Buoli, Massimiliano
AU - Ciappolino, Valentina
AU - Altamura, Alfredo Carlo
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Objectives: The treatment of bipolar disorder (BD) cannot be limited to the remission of acute phases but includes the long-term treatment in order to prevent relapses, poor outcome, and chronicity. The purpose of this article is to present 3 cases of severe psychotic bipolar patients treated with monthly injection of paliperidone pamoate. Methods: Three poor-compliant severe psychotic BD patients were initiated to paliperidone palmitate (100-150 mg monthly), and they were followed up for 12 months. Young Mania Rating Scale and Hamilton Depression Rating Scale were administered at baseline and during monthly follow-up visits. Results: None of patients presented recurrences or relapses during the 12-month follow-up period. The patients did not develop adverse effects or significant changes in metabolism. Conclusions: These preliminary results indicate that paliperidone palmitate (100-150mgmonthly)may be a therapeutic option for long-term treatment of psychotic BD, particularly for poor-compliant severe patients. These results have to be confirmed in double-blind studies with bipolar patients not necessarily belonging to psychotic subtype.
AB - Objectives: The treatment of bipolar disorder (BD) cannot be limited to the remission of acute phases but includes the long-term treatment in order to prevent relapses, poor outcome, and chronicity. The purpose of this article is to present 3 cases of severe psychotic bipolar patients treated with monthly injection of paliperidone pamoate. Methods: Three poor-compliant severe psychotic BD patients were initiated to paliperidone palmitate (100-150 mg monthly), and they were followed up for 12 months. Young Mania Rating Scale and Hamilton Depression Rating Scale were administered at baseline and during monthly follow-up visits. Results: None of patients presented recurrences or relapses during the 12-month follow-up period. The patients did not develop adverse effects or significant changes in metabolism. Conclusions: These preliminary results indicate that paliperidone palmitate (100-150mgmonthly)may be a therapeutic option for long-term treatment of psychotic BD, particularly for poor-compliant severe patients. These results have to be confirmed in double-blind studies with bipolar patients not necessarily belonging to psychotic subtype.
KW - Long-term treatment
KW - Paliperidone palmitate
KW - Psychotic bipolar disorder
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U2 - 10.1097/WNF.0000000000000103
DO - 10.1097/WNF.0000000000000103
M3 - Article
C2 - 26366967
AN - SCOPUS:84941915517
VL - 38
SP - 209
EP - 211
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
SN - 0362-5664
IS - 5
ER -