Palliative therapy for osteosarcoma

Costantino Errani, Alessandra Longhi, Giuseppe Rossi, Eugenio Rimondi, Alessio Biazzo, Angelo Toscano, Nikolin Alì, Pietro Ruggieri, Marco Alberghini, Piero Picci, Gaetano Bacci, Mario Mercuri

Research output: Contribution to journalArticle

Abstract

Despite advances in diagnostic imaging, the evolution of neoadjuvant chemotherapy and the refinements in limb-salvage surgery, the progression-free survival rate remains poor for patients with metastatic, recurrent or unresectable osteosaroma. Different therapeutic strategies for these subgroups of patients have been employed to control disease and prolong survival. Treatment options are limited and controversial, including systemic and localized therapies. Surgical resection, whenever feasible, is still the standard treatment in advanced osteosarcoma. The role of chemotherapy is unclear while the use of radiotherapy, embolization and thermal ablation is increasing. New therapeutic experimental approaches and novel target therapies are needed to improve the outcome of these subgroups of patients.

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalExpert Review of Anticancer Therapy
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • bone tumors
  • chemotherapy
  • embolization
  • osteosarcoma
  • palliation
  • radiotherapy
  • surgery
  • thermal ablation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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  • Cite this

    Errani, C., Longhi, A., Rossi, G., Rimondi, E., Biazzo, A., Toscano, A., Alì, N., Ruggieri, P., Alberghini, M., Picci, P., Bacci, G., & Mercuri, M. (2011). Palliative therapy for osteosarcoma. Expert Review of Anticancer Therapy, 11(2), 217-227. https://doi.org/10.1586/era.10.172