Palliative treatment of hepatocellular carcinoma with transcatheter arterial embolization

S. Savastano, G. P. Feltrin, D. Neri, P. da Pian, M. Chiesura-Corona, E. Roman, G. Battaglia, G. Gerunda, M. Lise, D. Miotto

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Abstract

Thirty-three consecutive patients with previously untreated hepatocellular carcinoma (HCC) and 6 patients with recurrent HCC were treated with transcatheter arterial embolization (TAE). The patients were not eligible for surgical resection or percutaneous ethanol injection. TAE was performed with Lipiodol Ultra-Fluid, epidoxorubicin and Gelfoam, with a mean of 1.7 treatments per patient. CT was performed 15 days after TAE. The mean cumulative survival was 14.2 months in patients with previously untreated HCC. The survival of patients stages Okuda I and II did not differ significantly (p>0.05); tumor size did not affect survival (p>0.05). Two patients with recurrent HCC died 7.0 and 9.3 months after the diagnosis of tumor recurrence; the remaining 4 patients are still alive with a maximum follow-up of 22.5 months from the diagnosis of HCC recurrence. Ten complications occurred in 8 patients, and were controlled by medical therapy. Eleven patients died during the study; no death was related to TAE. The series was not randomized, but comparison with the natural history of HCC suggests that TAE is effective as palliative treatment of advanced or recurrent HCC.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalActa Radiologica
Volume34
Issue number1
DOIs
Publication statusPublished - 1993

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Keywords

  • - therapeutic blockade
  • Doxorubicin
  • Hepatic arteries, chemotherapeutic infusion
  • Iodized oil, gelatin foam
  • Liver neoplasms therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Savastano, S., Feltrin, G. P., Neri, D., da Pian, P., Chiesura-Corona, M., Roman, E., Battaglia, G., Gerunda, G., Lise, M., & Miotto, D. (1993). Palliative treatment of hepatocellular carcinoma with transcatheter arterial embolization. Acta Radiologica, 34(1), 26-29. https://doi.org/10.1080/02841859309173231