Palliative treatments for advanced osteosarcoma

Andreas F. Mavrogenis, G. Rossi, E. Palmerini, C. Errani, E. Rimondi, R. Ruggieri, R. N. Soucacos, P. J. Papagelopoulos

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in diagnostic imaging, interventional radiology, chemotherapy and surgery greatly improved the outcome of patients with osteosarcoma, and made limb salvage possible without compromising survival. In these patients, the prognosis is influenced by the site and resectability of the tumor, prior malignancy, and histological response to preoperative chemotherapy. Unfortunately, the progress has not been as significant in the treatment of advanced osteosarcoma, namely metastatic, recurrent and unresectable tumor. Yet, although advanced and forecasting a dismal prognosis, advanced osteosarcoma is not necessarily untreatable. Aggressive local and medical treatments, including surgical removal of primary and/or metastatic disease are currently available; however, yet, most treatments aim at palliation. Palliative local treatments including isolated limb perfusion, radiation therapy, embolization, chemoembolization, thermal ablation and cryoablation, all have an important role for these patients. The aim of palliative treatments is to achieve a mild response by offering the least discomfort to the patient with the minimum possible complications, and possibly increase of survival.

Original languageEnglish
Pages (from-to)436-445
Number of pages10
JournalJournal of B.U.ON.
Volume17
Issue number3
Publication statusPublished - Jul 2012

Keywords

  • Advanced osteosarcoma
  • Palliative treatment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology
  • Radiology Nuclear Medicine and imaging

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