Aims: To assess the effect of substituting palm oil with other mairi dietary fats or oils on biomarkers of cardiovascular disease. Methods: We performed a systematic review and meta-analysis of dietary intervention trials. Studies were eligible if they included originai data comparing palm oil-rich diets with other fat-rich diets and analyzed at least one of the following lipid-related biomarkers: total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TC/HDL-C and LDL-C/HDL-C ratios, triacylglycerols, apolipoprotein A-I (apo A-I) and B (apo B), very low-density lipoprotein cholesterol, and lipoprotein (a). Results: Fifty-one studies were included, with fat substitutions ranging from 4 to 43%. When comparing palm oil diets with diets rich in stearic acid, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs), significanti higher levels of TC, LDL-C, apo B, HDL-C, and apo A-I were found, whereas most of the same biomarkers were significantly lower when compared with diets rich in myristic/lauric acid. Comparing palm oil-rich diets versus diets rich in trans fatty acids, significantly higher concentrations of HDL-C and apo A-I, and significantly lower concentrations of apo B and triacylglycerols, and ratios of TC/HDL-C, were observed. Stratified and meta-regression analyses showed that the higher concentrations of TC and LDL-C, when PO was substituted for MUFAs and PUFAs, were not significant in young people or in subjects with diets with a lower fat intake. Conclusions: Both favourable and unfavourable changes in cardiovascular risk biomarkers occurred when palm oil was substituted for the primary dietary fats, whereas only favorable changes occurred when palm oil was substituted for trans fatty acids.
|Number of pages||9|
|Journal||Ricerca e Pratica|
|Publication status||Published - May 1 2015|
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