Palmoplantar Keratoderma and Charcot-Marie-Tooth Disease

Giacomo Rabbiosi, Giovanni Borroni, Paolo Pinelli, Vittorio Cosi

Research output: Contribution to journalArticlepeer-review

Abstract

A close association was noted between palmoplantar keratoderma (PPK) and Charcot-Marie-Tooth disease (CMT) in nine members of a family in five generations. Clinical, genealogic, electroneurophysiologic, chromosome, urinary amino acid, and histopathologic studies were performed to define the two entities. Charco-Marie-Tooth disease occurred with advancing age in all of the members with PPK, but in none without PPK. Palmoplantar keratoderma and CMT appear to be genetically associated and transmitted as an autosomal dominant trait. This is the first report, to our knowledge, of an association between PPK and CMT.

Original languageEnglish
Pages (from-to)789-790
Number of pages2
JournalArchives of Dermatology
Volume116
Issue number7
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Dermatology

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