Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials

Luigi Celio; Erminio Bonizzoni; Emilio Bajetta; Silvia Sebastiani; Tania Perrone; Matti S. Aapro

doi:10.1007/s00520-012-1558-9

Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials

Luigi Celio, Erminio Bonizzoni, Emilio Bajetta, Silvia Sebastiani, Tania Perrone, Matti S. Aapro

Fondazione IRCCS Istituto Nazionale dei Tumori

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Abstract

Purpose: Data from two randomized trials, evaluating a single-day regimen of palonosetron plus dexamethasone against emesis due to moderately emetogenic chemotherapy, were assessed for the impact of age on outcome in a pooled sample of women receiving anthracycline and/or cyclophosphamide (AC)-containing chemotherapy. Methods: Chemo-naïve breast cancer patients randomized to receive palonosetron (0.25 mg) plus dexamethasone (8 mg IV) on day 1 of chemotherapy (n = 200), or the same regimen followed by oral dexamethasone (8 mg) on days 2 and 3 (n = 205), were included in the analysis. The primary endpoint was complete response (CR: no vomiting and no rescue anti-emetics) in the 5-day study period. The effect of the 1-day regimen and age (

Original language	English
Pages (from-to)	565-573
Number of pages	9
Journal	Supportive Care in Cancer
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/s00520-012-1558-9
Publication status	Published - Feb 2013

Keywords

AC-containing chemotherapy
Breast cancer
CINV
Dexamethasone
Meta-analysis
Palonosetron

ASJC Scopus subject areas

Oncology

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Celio, L., Bonizzoni, E., Bajetta, E., Sebastiani, S., Perrone, T., & Aapro, M. S. (2013). Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials. Supportive Care in Cancer, 21(2), 565-573. https://doi.org/10.1007/s00520-012-1558-9

Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy : Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials. / Celio, Luigi; Bonizzoni, Erminio; Bajetta, Emilio et al.

In: Supportive Care in Cancer, Vol. 21, No. 2, 02.2013, p. 565-573.

Research output: Contribution to journal › Article › peer-review

Celio, L, Bonizzoni, E, Bajetta, E, Sebastiani, S, Perrone, T & Aapro, MS 2013, 'Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials', Supportive Care in Cancer, vol. 21, no. 2, pp. 565-573. https://doi.org/10.1007/s00520-012-1558-9

Celio L, Bonizzoni E, Bajetta E, Sebastiani S, Perrone T, Aapro MS. Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials. Supportive Care in Cancer. 2013 Feb;21(2):565-573. https://doi.org/10.1007/s00520-012-1558-9

Celio, Luigi ; Bonizzoni, Erminio ; Bajetta, Emilio et al. / Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy : Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials. In: Supportive Care in Cancer. 2013 ; Vol. 21, No. 2. pp. 565-573.

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Palonosetron plus single-dose dexamethasone for the prevention of nausea and vomiting in women receiving anthracycline/cyclophosphamide-containing chemotherapy: Meta-analysis of individual patient data examining the effect of age on outcome in two phase III trials

Abstract

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