Palpebral syringomas and Down's syndrome

C. Schepis, M. Siragusa, R. Palazzo, R. M. Ragusa, G. Massi, G. Fabrizi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Palpebral syringomas have been reported to be more frequent in patients with Down's syndrome than in the normal population. Objective: The aim of the present study was to evaluate, in a population of institutionalized patients with Down's syndrome, the prevalence of syringomas and their possible cytogenetic relationships. Methods: Sixty-one institutionalized patients with Down's syndrome were examined in order to assess the presence of palpebral syringomas. Sixty mentally retarded non-Down's syndrome individuals were used as a control group. Results: Fourteen patients, 13 females and 1 male, were found to be affected. The prevalence of syringomas in both sexes was 23%; 42% of all females, and 55% when only adult females were considered had syringomas. Thirteen of the 14 affected patients had a karyotype of Down's syndrome with free trisomy 21, 1 had a mosaicism 47,XX,+21/46,XX. Histologic examination confirmed the diagnosis in all 4 biopsied cases. A clear-cell pattern was observed only in 1 patient while, sporadically, few tubules showed a central syringial-type cuticula. Conclusion: The higher prevalence found in females, as compared to males, can be partially explained by their older age (mean 23.8 vs. 13.9 years). Palpebral syringomas are a common cutaneous pathology in adult females with Down's syndrome.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalDermatology
Volume189
Issue number3
Publication statusPublished - 1994

Fingerprint

Syringoma
Eyelids
Down Syndrome
Mosaicism
Mentally Disabled Persons
Karyotype
Cytogenetics
Population
Pathology
Control Groups
Skin

Keywords

  • Down's syndrome
  • Mental retardation
  • Palpebral syringoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Schepis, C., Siragusa, M., Palazzo, R., Ragusa, R. M., Massi, G., & Fabrizi, G. (1994). Palpebral syringomas and Down's syndrome. Dermatology, 189(3), 248-250.

Palpebral syringomas and Down's syndrome. / Schepis, C.; Siragusa, M.; Palazzo, R.; Ragusa, R. M.; Massi, G.; Fabrizi, G.

In: Dermatology, Vol. 189, No. 3, 1994, p. 248-250.

Research output: Contribution to journalArticle

Schepis, C, Siragusa, M, Palazzo, R, Ragusa, RM, Massi, G & Fabrizi, G 1994, 'Palpebral syringomas and Down's syndrome', Dermatology, vol. 189, no. 3, pp. 248-250.
Schepis C, Siragusa M, Palazzo R, Ragusa RM, Massi G, Fabrizi G. Palpebral syringomas and Down's syndrome. Dermatology. 1994;189(3):248-250.
Schepis, C. ; Siragusa, M. ; Palazzo, R. ; Ragusa, R. M. ; Massi, G. ; Fabrizi, G. / Palpebral syringomas and Down's syndrome. In: Dermatology. 1994 ; Vol. 189, No. 3. pp. 248-250.
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