Pancreas preservation with University of Wisconsin and celsior solutions: A single-center, prospective, randomized pilot study

Ugo Boggi, Fabio Vistoli, Marco Del Chiaro, Stefano Signori, Chiara Croce, Andrea Pietrabissa, Raffaella Berchiolli, Piero Marchetti, Stefano Del Prato, Franco Mosca

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Celsior is an extracellular-type, low-viscosity, preservation solution already used for heart, lung, liver, and kidney transplantation. We report the results of a single-center, prospective, randomized pilot study specifically designed to compare the safety profile of Celsior solution with University of Wisconsin (UW) solution in clinical pancreas transplantation. Methods. A total of 105 consecutive procurements were randomized to graft preservation with UW (n=53) solution or Celsior (n=52) solution. The groups were comparable with regard to all donor and recipient characteristics. Results. Five grafts were discarded and 100 grafts (50 UW vs. 50 Celsior) were transplanted. Mean cold and warm ischemia times were 11.0±2.1 hr and 37.2±6.0 min for UW compared with 10.8±1.8 hr and 38.1±5.9 min for Celsior (P=not significant). Delayed endocrine pancreas function was recorded in one graft preserved with UW solution. Eleven recipients (UW 12% vs. Celsior 10%, P=not significant) required a relaparotomy. The mean serum levels of glucose, amylase, and lipase remained comparable between the study arms at equivalent intervals after transplantation. One recipient died with functioning grafts in each study arm; two further grafts were lost to arterial thrombosis (Celsior) and chronic rejection (UW), respectively. Actuarial 1-year patient and graft survival rates overlapped in the two study arms (98% and 96%, respectively). Conclusions. Within the range of cold ischemia time reported in this study, UW and Celsior solutions have similar safety profiles for pancreas preservation.

Original languageEnglish
Pages (from-to)1186-1190
Number of pages5
JournalTransplantation
Volume77
Issue number8
Publication statusPublished - Apr 27 2004

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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