Pancreatic β-cell damage. In search of novel pathogenetic factors

G. F. Bottazzo, A. K. Foulis, E. Bosi, I. Todd, R. Pujol-Borrell

Research output: Contribution to journalArticle


A model for the possible pathogenesis of insulin-dependent diabetes mellitus (IDDM) is presented. It is partly based on studies of autoimmune thyroiditis and founded on the idea that inappopriate class II molecule expression in insulin-producing β-cells of pancreatic islets could cause an organ-specific autoimmune disorder. The model is supported by results of several IDDM case studies as well as by the critical evaluation of the known effects of various lymphokines and lymphotoxins on endocrine target tissues. The possible roles of islet capillary endothelial cells and islet cell antibodies in the pathogenesis of IDDM are discussed.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalDiabetes Care
Issue numberSUPPL. 1
Publication statusPublished - 1988


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Bottazzo, G. F., Foulis, A. K., Bosi, E., Todd, I., & Pujol-Borrell, R. (1988). Pancreatic β-cell damage. In search of novel pathogenetic factors. Diabetes Care, 11(SUPPL. 1), 24-28.