Pancreatic cancer

Marcello Orsi; Claudio Losio; Michele Reni; Nadia Di Muzio; Francesco De Cobelli; Alessandro Del Maschio

doi:10.1007/978-88-470-2613-1_8

Pancreatic cancer

Marcello Orsi, Claudio Losio, Michele Reni, Nadia Di Muzio, Francesco De Cobelli, Alessandro Del Maschio

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

While pancreatic cancer has an inherited or rapidly acquired chemoresistance, a meta-analysis of data from published clinical trials reported a significant improvement in overall survival (OS) among patients receiving chemotherapy [1]. Nowadays, gemcitabine is widely accepted as the standard first-line therapy and as the reference treatment arm for clinical trials in this patient population [2, 3]. However, its anti-tumoral activity is disappointing because the response rate is around 10%, median survival about 6 months, and 1-year OS around 20%.

Original language	English
Title of host publication	Imaging Tumor Response to Therapy
Publisher	Springer-Verlag Italia s.r.l.
Pages	127-140
Number of pages	14
ISBN (Print)	9788847026131, 9788847026124
DOIs	https://doi.org/10.1007/978-88-470-2613-1_8
Publication status	Published - Jan 1 2012

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-88-470-2613-1_8

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AU - Orsi, Marcello

AU - Losio, Claudio

AU - Reni, Michele

AU - Muzio, Nadia Di

AU - De Cobelli, Francesco

AU - Maschio, Alessandro Del

PY - 2012/1/1

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N2 - While pancreatic cancer has an inherited or rapidly acquired chemoresistance, a meta-analysis of data from published clinical trials reported a significant improvement in overall survival (OS) among patients receiving chemotherapy [1]. Nowadays, gemcitabine is widely accepted as the standard first-line therapy and as the reference treatment arm for clinical trials in this patient population [2, 3]. However, its anti-tumoral activity is disappointing because the response rate is around 10%, median survival about 6 months, and 1-year OS around 20%.

AB - While pancreatic cancer has an inherited or rapidly acquired chemoresistance, a meta-analysis of data from published clinical trials reported a significant improvement in overall survival (OS) among patients receiving chemotherapy [1]. Nowadays, gemcitabine is widely accepted as the standard first-line therapy and as the reference treatment arm for clinical trials in this patient population [2, 3]. However, its anti-tumoral activity is disappointing because the response rate is around 10%, median survival about 6 months, and 1-year OS around 20%.

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BT - Imaging Tumor Response to Therapy

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Pancreatic cancer

Abstract

ASJC Scopus subject areas

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