Abstract
Our knowledge of the etiology of all forms of cancer including pancreatic cancer has improved dramatically in the second half of this century. The current model describes a gradual change from a normal pancreatic cell to a fully malignant cell requiring several stages with gradual and progressive alterations appearing at the genetic and the tissue level. Although there are many germ line diseases that are associated with pancreatic cancer it is probable that inherited diseases account for only about 10% of the total burden of pancreatic cancer. Avoidance of smoking and dietary modification are the current best strategies for reducing the risk of this tumor. In addition, newer molecular techniques and imaging procedures should provide clinicians with the ability to detect pancreatic cancer at an early, potentially curable stage.
| Original language | English |
|---|---|
| Pages (from-to) | 191-200 |
| Number of pages | 10 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 880 |
| DOIs | |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Pancreatic cancer : Development of a unifying etiologic concept. / Lowenfels, Albert B.; Maisonneuve, Patrick.
In: Annals of the New York Academy of Sciences, Vol. 880, 1999, p. 191-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pancreatic cancer
T2 - Development of a unifying etiologic concept
AU - Lowenfels, Albert B.
AU - Maisonneuve, Patrick
PY - 1999
Y1 - 1999
N2 - Our knowledge of the etiology of all forms of cancer including pancreatic cancer has improved dramatically in the second half of this century. The current model describes a gradual change from a normal pancreatic cell to a fully malignant cell requiring several stages with gradual and progressive alterations appearing at the genetic and the tissue level. Although there are many germ line diseases that are associated with pancreatic cancer it is probable that inherited diseases account for only about 10% of the total burden of pancreatic cancer. Avoidance of smoking and dietary modification are the current best strategies for reducing the risk of this tumor. In addition, newer molecular techniques and imaging procedures should provide clinicians with the ability to detect pancreatic cancer at an early, potentially curable stage.
AB - Our knowledge of the etiology of all forms of cancer including pancreatic cancer has improved dramatically in the second half of this century. The current model describes a gradual change from a normal pancreatic cell to a fully malignant cell requiring several stages with gradual and progressive alterations appearing at the genetic and the tissue level. Although there are many germ line diseases that are associated with pancreatic cancer it is probable that inherited diseases account for only about 10% of the total burden of pancreatic cancer. Avoidance of smoking and dietary modification are the current best strategies for reducing the risk of this tumor. In addition, newer molecular techniques and imaging procedures should provide clinicians with the ability to detect pancreatic cancer at an early, potentially curable stage.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032795567&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.1999.tb09523.x
DO - 10.1111/j.1749-6632.1999.tb09523.x
M3 - Article
VL - 880
SP - 191
EP - 200
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -