TY - JOUR
T1 - Pancreatic cancer in chronic pancreatitis; Aetiology, incidence, and early detection
AU - Raimondi, Sara
AU - Lowenfels, Albert B.
AU - Morselli-Labate, Antonio M.
AU - Maisonneuve, Patrick
AU - Pezzilli, Raffaele
PY - 2010/6
Y1 - 2010/6
N2 - Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute pancreatitis can lead to irreversible changes characteristic of chronic pancreatitis. In recent decades accumulating evidence has defined longstanding pre-existing chronic pancreatitis as a strong risk factor for pancreatic cancer. The lag period between diagnosis of chronic pancreatitis and pancreatic cancer is usually one or two decades: pancreatitis appearing a year or two before the diagnosis of pancreatic cancer is often the result of tumour-related ductal obstruction. The risk of developing pancreatic cancer appears to be highest in rare types of pancreatitis with an early onset, such as hereditary pancreatitis and tropical pancreatitis. Even though there is a strong link between chronic pancreatitis and pancreatic cancer, over a 20 year period only around five percent of patients with chronic pancreatitis will develop pancreatic cancer. Until the development of more sophisticated screening procedures, screening is not recommended for patients with chronic pancreatitis.
AB - Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute pancreatitis can lead to irreversible changes characteristic of chronic pancreatitis. In recent decades accumulating evidence has defined longstanding pre-existing chronic pancreatitis as a strong risk factor for pancreatic cancer. The lag period between diagnosis of chronic pancreatitis and pancreatic cancer is usually one or two decades: pancreatitis appearing a year or two before the diagnosis of pancreatic cancer is often the result of tumour-related ductal obstruction. The risk of developing pancreatic cancer appears to be highest in rare types of pancreatitis with an early onset, such as hereditary pancreatitis and tropical pancreatitis. Even though there is a strong link between chronic pancreatitis and pancreatic cancer, over a 20 year period only around five percent of patients with chronic pancreatitis will develop pancreatic cancer. Until the development of more sophisticated screening procedures, screening is not recommended for patients with chronic pancreatitis.
KW - Acute pancreatitis
KW - Chronic pancreatitis
KW - Epidemiology
KW - Hereditary pancreatitis
KW - Kras
KW - Pancreas
KW - Pancreatic cancer
KW - Pancreatitis
KW - Tropical pancreatitis
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U2 - 10.1016/j.bpg.2010.02.007
DO - 10.1016/j.bpg.2010.02.007
M3 - Article
C2 - 20510834
AN - SCOPUS:77956194328
VL - 24
SP - 349
EP - 358
JO - Bailliere's Best Practice and Research in Clinical Gastroenterology
JF - Bailliere's Best Practice and Research in Clinical Gastroenterology
SN - 1521-6918
IS - 3
ER -